Gastrointestinal stromal tumors (GISTs) are a type of rare cancer that develop in the cells that form the supportive tissue in the wall of the gastrointestinal (GI) tract. Symptoms may include abdominal pain, bloating, nausea, and weight loss. GISTs can occur anywhere in the GI tract, but are most commonly found in the stomach and small intestine. Diagnosis is typically made through imaging studies and biopsy. Treatment options may include surgery, imatinib (a type of targeted therapy), and other medications. The choice of treatment depends on the size and location of the tumor and the overall health of the patient. It is important to seek medical attention if you experience symptoms that may be related to a GIST.