Tigecycline is indicated for the following infections-

• Skin infections caused by susceptible organisms.
• Intra-abdominal infections.
• Community acquired pneumonia caused by Hemophilus influenza and Legionella spp.

Skin Infection

Abdominal Infection

Community acquired pneumonia

• For adults, a starting dose of 100 mg is advised, followed by 50 mg every 12 hours for 5 to 14 days. The length of treatment should be determined by the severity of the illness, its location, and the patient's clinical response.
• Tigecycline should only be used to treat patients aged 8 and up after consulting with a physician with relevant experience in infectious illness care. Children aged 8 to <12 years: 1.2 mg/kg of tigecycline every 12 hours intravenously to a maximum dose of 50 mg every 12 hours for 5 to 14 days.
• Adolescents aged 12 to <18 years: 50 mg of tigecycline every 12 hours for 5 to 14 days.
• The dose of tigecycline should be reduced by half in individuals (including children) with severe hepatic impairment. Following the 100 mg loading dosage, the adult dose should be lowered to 25 mg every 12 hours. Patients with severe hepatic impairment should be handled with caution and their treatment responses should be closely monitored.

The side effects associated with tigecycline is usually mild. They include-

• Nausea
• Vomiting
• Diarrhea
• Phlebitis
• Dizziness
• Dyspepsia

Nausea	Vomiting	Diarrhea
Dizziness	Dyspepsia	Phlebitis

• Tigecycline should be used with caution in patients with hepatic problems.
• Pancreatitis have also been reported with the use of tigecycline.
• Superinfection by resistant organisms may occur.
• Anaphylaxis/anaphylactoid reactions, potentially life-threatening, have been reported with tigecycline