Adrenaline + Lidocaine Hydrochloride is indicated for the following conditions-

• Local pain
• Local anesthesia

Local pain

Local Anesthesia

The recommended doses serve only as a guide to the amount of anesthetic required for most routine procedures. The actual volumes and concentrations to be used depend on a number of factors such as type and extent of surgical procedure, depth of anesthesia and degree of muscular relaxation required, duration of anesthesia required, and the physical condition of the patient. In all cases the lowest concentration and smallest dose that will produce the desired result should be given. Dosages should be reduced for children and for the elderly and debilitated patients and patients with cardiac and/or liver disease.  

For epidural anesthesia, only the following dosage forms Lidocaine+ adrenaline Injection are recommended:

• 1% with epinephrine: 30 mL single dose solutions 
• 1.5% with epinephrine: 30 mL ampules, 30 mL single dose solutions
• 2% with epinephrine: 20 mL ampules, 20 mL single dose solutions 

For intravenous regional anesthesia, only the 50 mL single dose vial containing lidocaine HCl 0.5% Injection should be used.  

For normal healthy adults, the individual maximum recommended dose of lidocaine HCl with epinephrine should not exceed 7 mg/kg (3.5 mg/lb) of body weight, and in general it is recommended that the maximum total dose not exceed 500 mg.

Common adverse reactions are application site reactions such as-

• irritation
• erythema
• pruritus

Skin Irritation

Erythema

Pruritus

• Accidental Exposure: Even a used Lidocaine HCl topical system contains residual Lidocaine HCl after use.  It is important for patients to store and dispose of Lidocaine HCl properly and keep out of the reach of children, pets, and others.
• Excessive Dosing/Overexposure: Applying Lidocaine HCl to larger surface areas or for a longer duration than recommended could lead to increased absorption and high blood concentrations of Lidocaine HCl, leading to adverse effects
• Increased Absorption on Non-Intact Skin: May result in higher blood concentrations of Lidocaine HCl
• Risk of Overexposure with External Heat Sources: Applying external heat sources to Lidocaine HCl may result in increased drug exposure 
• Methemoglobinemia: Cases of methemoglobinemia have been reported in association with local anesthetic use
• Application Site Reactions: During or immediately after treatment with Lidocaine HCl, application site reactions may develop 
• Hypersensitivity Reactions: Cross sensitivity to Lidocaine HCl in patients with a history of drug sensitivity to para-aminobenzoic acid (PABA) derivatives is possible
• Eye Exposure: Immediately wash out the eye with water or saline and protect the eye until sensation returns