Amlodipine + Olmesartan Medoxomil is indicated for the treatment of essential hypertension. It is used to treat adults with high blood pressure who aren't obtaining significant improvement on amlodipine or valsartan alone.

Hypertension (Hight Blood Pressure)

• Patients who cannot regulate their blood pressure with 20 mg olmesartan medoxomil or 5 mg amlodipine alone may be given Olmesartan + Amlodipine 20 mg/5 mg.
• Patients whose blood pressure is not regulated properly by Olmesartan + Amlodipine 20 mg/5 mg may be given Olmesartan + Amlodipine 40 mg/5 mg.
• Patients whose blood pressure is not regulated effectively by Olmesartan + Amlodipine 40 mg/5 mg may be given Olmesartan + Amlodipine 40 mg/10 mg.
• Before switching to the fixed combination, a step-by-step titration of the individual component dosage is recommended. Direct switching from monotherapy to the fixed combination may be undertaken when clinically suitable.
• Patients getting separate tablets of olmesartan medoxomil and amlodipine may be switched to Olmesartan + Amlodipine tablets containing the same component doses for convenience.

Dosage Adjustment:

Renal impairment: Due to limited experience with larger dosages in this patient population, the maximum dose of olmesartan medoxomil in patients with mild to moderate renal impairment (creatinine clearance of 20–60 mL/min) is 20 mg olmesartan medoxomil once daily. Sevikar should not be used in patients with severe renal impairment (creatinine clearance less than 20 mL/min).

Hepatic impairment: An initial dose of 10 mg olmesartan medoxomil once day is indicated for patients with moderate hepatic impairment, with a maximum dose of 20 mg once daily.

Common side effects associated with Amlodipine + Olmesartan are-

• Dizziness
• Headache
• Edema
• Flushing

Dizziness

Headache

Edema

Flushing

• During the second and third trimesters of pregnancy, medications that act on the renin-angiotensin system impair fetal renal function and increase fetal and newborn morbidity and death.
• 0.4 percent of patients with simple hypertension treated with Amlodipine + Omlesartan medoxomil experienced excessive hypotension. Angiotensin receptor blockers may cause symptomatic hypotension in individuals with an active renin-angiotensin system, such as volume- and/or salt-depleted patients receiving high doses of diuretics.
• In patients with heart failure or a recent myocardial infarction, as well as those undergoing surgery or dialysis, start therapy carefully.