Medicine details

ImageAmoclav 600
NameAmoclav 600
DosageInjection
Generic NameAmoxicillin + Clavulanic Acid
Classes Penicillin
Antibiotic Combination
Antiinfective Agent
Diseases Bronchitis
Ear Infection
Infectious Disease
Pneumonia
Sinusitis
UTI (Urinary Tract Infection)
CompanyTechno Drugs Ltd.

Drug Package Details

Strength500 mg + 100 mg
Storage Condition
Origin CountryBangladesh
Commercial Pack1
Price per pack135.00
Cost per pack118.80
Package unit500 mg +100 mg vial
Price per unit135.00
Cost per unit118.80
Discount0
Coupon
Remarks

Amoxicillin + Clavulanic Acid

Amoxicillin+ clavulanic acid is a combination drug of amoxicillin and clavulanic acid, often called Augmentin. Amoxicillin is a broad spectrum penicillin of the beta lactam group of antibiotics. Clavulanic acid is a beta lactamase enzyme inhibitor. Beta lactamase is produced by certain strains of gram positive and gram negative bacteria which destroys beta lactam antibiotics (amoxicillin, ampicillin, cefazolin etc.) and nullifies their efficacy. 

Amoxicillin + Clavulanic Acid is used for the treatment of following diseases-

  • Lower Respiratory Tract Infections caused by beta lactamase producing strains of H. influenzae and
    M. catarrhalis.
  • Otitis Media – caused by β-lactamase–producing strains of H. influenzae and M. catarrhalis.
  • Sinusitis – caused by β-lactamase–producing strains of H. influenzae and M. catarrhalis.
  • Skin and Skin Structure Infections – caused by β-lactamase–producing strains of S. aureus, E. coli,
    and Klebsiella spp.
  • Urinary Tract Infections – caused by β-lactamase–producing strains of E. coli, Klebsiella spp. and
    Enterobacter spp. 

Amoxicillin + clavulanic acid can be taken without regarding meals, but absorption of clavulanate is better when the medication is taken before meals.

Adults and children over 12 years:

Tablet:

  • The usual adult dose is one 625 mg Tablet every 12 hours or one 375 mg Tablet every 8 hours.
  • For more severe infections and infections of the respiratory tract, the dose should be one 1 gm Tablet every 12 hours or one 625 mg Tablet every 8 hours.

Suspension:

  • Children 6-12 years: 2 teaspoonful every 8 hours.
  • Children 1-6years: 1 teaspoonful every 8 hours.
  • Children below 1 year: 25 mg/kg/day in divided doses every 8 hours, for example a 7.5 kg child would require 2 ml suspension t.i.d, Treatment should not be extended beyond 14 days without review.

Forte suspension:

  • The usual recommended daily dosage: 25/3.6 mg/kg/day in mild to moderate infections (upper respiratory tract infections e.g. recurrent tonsilitis, lower respiratory infections, and skin and soft tissue infections)।
  • For serious infections: 45/6.4 mg/kg/day for the treatment of more serious infections (upper respiratory tract infections, e.g. otitis media and sinusitis, lower respiratory infections e.g. bronchopneumonia, and urinary tract infections).

How to reconstitute powder for suspension:

Children of 2 to 12 years:
Mild to moderate infections:

  • 25/3.6 mg/kg/day (Suspension)
  • 2-6 years (13-21 kg) 2.5 ml suspension b.i.d
  • 7-12years (22-40kg) 5 ml suspension b.i.d

Serious infections:

  • 45/6.4 mg/kg/day (Forte Suspension)
  • 2-6 years (13-21 kg) 5 ml suspension b.i.d
  • 7-12 years (22-40 kg) 10 ml suspension b.i.d

IV Injection

Adults-

  • Usually, 1.2 gm every 8 hours
  • Increased in more serious infections to 1.2 gm every 6 hours
  • For surgical prophylaxis: The usual dose is 1.2 gm at induction, for high risk procedures (eg. colorectal surgery) up to 2-3 gm may be given every 8 hours.

Children-

  • 0 to 3 months: 30 mg/kg every 8 hours. (every 12 hours in the perinatal period and in premature infants.
  • 3 months to 12 years: Usually 30 mg/kg every 8 hours increased in more serious infection to 30 mg/kg every 6 hours.

The side effects of amoxicillin + clavulanic acid is usually mild. The most common side effects is Clostridium difficile associated diarrhea. Incidents of rash have also been reported. A rare but serious side effect is hypersensitivity reaction.

  • Some patients may show hypersensitivity reactions to amoxicillin + clavulanic acid. In such cases treatment should be stopped immediately.
  • Superinfection of resistant organisms like C.difficile may occur.
  • Amoxicillin causes an erythematous skin rash in a large percentage of mononucleosis individuals. As a result, amoxicillin should not be given to mononucleosis patients.

Contraindication

Amoxicillin + clavulanic acid is contraindicated in patients who are hypersensitive to beta lactam antibiotics such as-

There is no known contraindications of amoxicillin + clavulanic acid in terms of food & drinks.

It is contraindicated in patients with a previous history of cholestatic jaundice/hepatic dysfunction associated with amoxicillin + clavulanic acid.