Medicine details
Image | |
Name | Ripril PLUS 2.5/12.5 |
Dosage | Tablet |
Generic Name | Hydrochlorothiazide + Ramipril |
Classes |
Cardiovascular Agent Antihypertensive Antihypertensive Combination |
Diseases |
Cardiovascular Disease Hypertension (High Blood Pressure) |
Company | Square Pharmaceuticals Ltd. |
Drug Package Details
Strength | 12.5 mg + 2.5 mg |
Storage Condition | |
Origin Country | Bangladesh |
Commercial Pack | 30 |
Price per pack | ৳ 150.88 |
Cost per pack | ৳ 132.77 |
Package unit | 10 tabs strip |
Price per unit | ৳ 5.03 |
Cost per unit | ৳ 4.43 |
Discount | 0 |
Coupon | |
Remarks |
Hydrochlorothiazide + Ramipril
Hydrochlorothiazide + Ramipril is a combination medicine used to treat hypertension. Hydrochlorothiazide is a thiazide diuretic which inhibits Na+ and Cl- reabsorption which in turn impairs water reabsorption. Ramipril is a angiotensin converting enzyme inhibitor. As a result vasoconstriction due to angiotensin II is inhibited.
Hydrochlorothiazide + Ramipril is indicated for the treatment of essential hypertension in Adults.
- Ramipril + Hydrochlorothiazide is available as tablets.
- If ramipril (or another ACE inhibitor such as) or hydrochlorothiazide (or another thiazide diuretic) alone fails to manage blood pressure, the patient may be shifted to combination therapy with Ramipril 2.5 mg + Hydrochlorothiazide 12.5 mg or Ramipril 5 mg + Hydrochlorothiazide 25 mg tablet.
- A maximum dose of 10 mg ramipril and 50 mg hydrochlorothiazide (four tablets of Ramipril 2.5 mg + Hydrochlorothiazide 12.5 mg or two tablets of Ramipril 5 mg + Hydrochlorothiazide 25 mg) is allowed
Renal Impairment: Treatment with Ramipril 1.25 mg monotherapy should be started in patients with a creatinine clearance of 60 to 30 ml/min. If blood pressure isn't regulated well enough, Ramipril's dose might be increased to 2.5 mg. If blood pressure still isn't under control, the patient may be transferred to Ramipril + Hydrochlorothiazide 5 mg+25 mg once a day.
Caution should be exercised when treating following group of patients with Ramipril + Hydrochlorothiazide-
- Patients with heart failure
- Salt and volume depleted patients
- Patients with renal artery stenosis
- Patients with activated RAAS system
Contraindication
- Ramipril + Hydrochlorothiazide is contraindicated in patients hypersensitive to Ramipril or other ACEIs such as-
-
and patients who are sensitive to hydrochlorothiazide or to other sulfonamide-derived drugs, such as
Ramipril + Hydrochlorothiazide is contraindicated in the following health conditions-
- Pregnancy
- Severe kidney problems
- Severe liver problems