Medicine details

ImageValzide 80/12.5
NameValzide 80/12.5
DosageTablet
Generic NameHydrochlorothiazide + Valsartan
Classes Cardiovascular Agent
Antihypertensive
Antihypertensive Combination
Diseases Cardiovascular Disease
Hypertension (High Blood Pressure)
CompanyRenata Limited

Drug Package Details

Strength12.5 mg + 80 mg
Storage Condition
Origin CountryBangladesh
Commercial Pack20
Price per pack220.00
Cost per pack193.60
Package unit10 tabs strip
Price per unit11.00
Cost per unit9.68
Discount0
Coupon
Remarks

Hydrochlorothiazide + Valsartan

Hydrochlorothiazide + Valsartan is a combination of valsartan, an orally active, AT1 receptor subtype specific angiotensin II receptor blocker (ARB), and hydrochlorothiazide, a diuretic.

 

This combination is used to treat Hypertension.

  • Hydrochlorothiazide + Valsartan is available as tablets. 
  • Hydrochlorothiazide + Valsartan 160/12.5 mg once day is the usual beginning dose. After 1 to 2 weeks of therapy, the dosage can be increased to a maximum of one 320/25 tablet once day as needed to regulate blood pressure. After a dosage modification, the maximum antihypertensive effects are achieved in 2 to 4 weeks.

The side effects associated with the medication are as follows-

  • headache
  • dizziness
  • Pharyngitis
  • Hypotension
  • Tinnitus
  • Dyspepesia
  • Asthenia
  • During the second and third trimesters of pregnancy, medications that act on the renin-angiotensin system impair fetal renal function and increase fetal and newborn morbidity and death.
  • In controlled trials, patients with uncomplicated hypertension treated with Hydrochlorothiazide + Valsartan experienced a very little (0.7 percent) drop in blood pressure. Symptomatic hypotension can occur in patients with an active renin-angiotensin system, such as volume- and/or salt-depleted patients on high doses of diuretics.

Contraindication

  •  Contraindicated to the patients who are sensitive to hydrochlorothiazide or to other sulfonamide-derived drugs, such as-
  • Contraindicated to the patients who are sensitive to valsartan or other ARBs, such as-
  • Concomitant use of Hydrochlorothiazide + Valsartan with aliskiren containing products in patients with diabetes mellitus or renal impairment.
  • Hydrochlorothiazide + Valsartan is contraindicated in pregnancy.
  • Hydrochlorothiazide + Valsartan is contraindicated in patients with severe kidney problems (GFR 30 mL/min) and anuria due to the hydrochlorothiazide component.
  • Hydrochlorothiazide + Valsartan is contraindicated in patients with significant hepatic problems or biliary cirrhosis and cholestasis due to the valsartan component.