Medicine details

ImageAdecef 500
NameAdecef 500
DosageCapsule
Generic NameCephradine
Classes Anti-infective Agent
Antibiotic
Cephalosporine
Diseases Bronchitis
Gonorrhea
Infectious Disease
Meningitis
Otitis
Pneumonia
Sinusitis
Tonsillitis
Urethritis
CompanySupreme Pharmaceuticals Ltd.

Drug Package Details

Strength500 mg
Storage Condition
Origin CountryBangladesh
Commercial Pack24
Price per pack৳ 300.00
Cost per pack৳ 264.00
Package unit6 caps strip
Price per unit৳ 12.50
Cost per unit৳ 11.00
Discount0
Coupon
Remarks

Cephradine

Cephradine is a first generation cephalosporin belonging to a class of antibiotics called the beta lactams. It kills bacteria by inhibiting bacterial cell wall synthesis.

Cephradine is indicated for the following infections-

  • Upper respiratory tract infections - sinusitis, pharyngitis, tonsillitis, laryngo-tracheo bronchitis and otitis media.
  • Lower respiratory tract infections - acute and chronic bronchitis, lobar and bronchopneumonia.
  • Urinary tract infections - cystitis, urethritis and pyelonephritis.
  • Skin and soft tissue infections - impetigo, abscess, cellulitis, furunculosis.

 

Cephradine is available as capsules, powder for suspension and pediatric drops.

Adults:

  • Infections of the respiratory tract and skin and soft tissue - the usual dose is 250mg or 500mg four times a day, or 500mg or 1g twice a day, depending on the severity and location of the illness.
  • The standard dose for urinary tract infections is 500mg four times a day or 1g twice a day. For severe or chronic infections, this may need to be increased. Complications including prostatitis and epididymitis require long-term intense treatment,

Pediatric patients:
The typical dose is 25 to 50 mg/kg/day, divided into two or four equal doses. Daily doses of 75 to 100mg/kg in divided doses every 6 to 12 hours are indicated for otitis media. The maximum daily dose is 4g.

How to reconstitute powder for suspension:

How to administer paediatric drops:
  • Dosage adjustment is required for renally impaired patients.

Side effects associated with the use of cephradine are-

  • Thrombocytopenia
  • Anemia
  • Pseudomembranous colitis
  • Dizziness
  • Headache
  • Liver problems
  • Nausea
  • Although very rare, Hypersensitivity reactions may occur in some patients.
  • Prolonged use of Cephradine may cause the overgrowth of resistant organisms like Candida sp. and Clostridium difficile. 
  • Patient might experience Clostridium difficile associated diarrhea with prolonged use of cephalexin.
  • Taking alcohol while on treatment with cephradine can cause disulfiram like reaction.
  • Patients with renal impairment may require dosage adjustment.

Contraindication

Contraindicated in patients hypersensitive to any beta lactam antibiotics such as-