Medicine details

ImageBinoclar 500
NameBinoclar 500
DosageTablet
Generic NameClarithromycin
Classes Antiinfective Agent
Antibiotic
Dermatological/Topical Agent
Topical Antiinfective Agent
Respiratory Agent
Macrolide
Diseases H. pylori Infection
Infectious Disease
Pharyngitis
RTI (Respiratory Tract Infection)
Sinusitis
Tonsillitis
CompanyNovartis (Bangladesh) Ltd.

Drug Package Details

Strength500 mg
Storage Condition
Origin CountryBangladesh
Commercial Pack14
Price per pack938.00
Cost per pack825.44
Package unit7 tabs strip
Price per unit67.00
Cost per unit58.96
Discount0
Coupon
Remarks

Clarithromycin

Clarithromycin is a semi synthetic macrolide antibiotic. It binds to the 50s subunit of the bacterial ribosome and inhibits protein synthesis. It is available as immediate-release tablets, extended-release tablets, and granules for oral suspension. 

Clarithromycin is indicated for the following infections-

  • Pharyngitis/Tonsillitis due to Streptococcus pyogenes
  • Acute maxillary sinusitis due to Haemophilus influenzae, Moraxella catarrhalis or Streptococcus pneumoniae.
  • Community-Acquired Pneumonia due to Haemophilus influenzae, Mycoplasma pneumoniae, Streptococcus
    pneumoniae, or Chlamydia pneumoniae
  • Uncomplicated skin and skin structure infections
  • Duodenal ulcer due to Helicobacter pylori (combined with amoxicillin+lansoprazole)
  • Clarithromycin is available as tablets, suspension and Intravenous/intramuscular injection.
  • The adult dose for clarithromycin can vary between 250-400 gm depending on the type and severity of the infection and therapy last up to 14 days. Clarithromycin can be taken with or without meals.
  • The dose of clarithromycin should be reduced by half in patients with severe renal impairment (CLCR 30 mL/min). When taking clarithromycin with atazanavir or ritonavir in patients with moderate or severe renal impairment, the dose of clarithromycin should be reduced by 50% or 75% for individuals with CLCR of 30 to 60 mL/min or 30 mL/min, respectively.

The majority of side effects observed in clinical trials were of a mild and transient nature. The most frequent side effects of clarithromycin are-

  • Diarrhea
  • Nausea
  • Dyspepsia
  • Abnormal taste
  • Abdominal pain
  • Patients with hepatic impairment and normal renal function can take clarithromycin without changing their dosage. Reduced dosage or longer dosing intervals may be recommended in the context of severe renal impairment with or without concurrent hepatic impairment.
  • In patients taking clarithromycin therapy, symptoms of myasthenia gravis have worsened and new signs of myasthenic syndrome have appeared.
  • In patients with a history of acute porphyria, clarithromycin in conjunction with ranitidine bismuth citrate should be avoided.

Contraindication

  • Clarithromycin is contraindicated in patients with a known hypersensitivity to macrolide antibiotics such as-
  • Concomitant administration of clarithromycin and any of the following drugs is contraindicated-
  • Concomitant administration of clarithromycin and colchicine is contraindicated in patients with renal or hepatic impairment.

There is no known contraindications of clarithromycin in terms of food and drinks.

Clarithromycin is contraindicated in patients with a history of cholestatic jaundice/hepatic dysfunction associated with prior use of clarithromycin.