Medicine details
Image | |
Name | Clarison 500 |
Dosage | Tablet |
Generic Name | Clarithromycin |
Classes |
Antiinfective Agent Antibiotic Dermatological/Topical Agent Topical Antiinfective Agent Respiratory Agent Macrolide |
Diseases |
H. pylori Infection Infectious Disease Pharyngitis RTI (Respiratory Tract Infection) Sinusitis Tonsillitis |
Company | Hudson Pharmaceuticals Ltd. |
Drug Package Details
Strength | 500 mg |
Storage Condition | |
Origin Country | Bangladesh |
Commercial Pack | 10 |
Price per pack | ৳ 450.00 |
Cost per pack | ৳ 396.00 |
Package unit | 10 tabs strip |
Price per unit | ৳ 45.00 |
Cost per unit | ৳ 39.60 |
Discount | 0 |
Coupon | |
Remarks |
Clarithromycin
Clarithromycin is a semi synthetic macrolide antibiotic. It binds to the 50s subunit of the bacterial ribosome and inhibits protein synthesis. It is available as immediate-release tablets, extended-release tablets, and granules for oral suspension.
Clarithromycin is indicated for the following infections-
- Pharyngitis/Tonsillitis due to Streptococcus pyogenes
- Acute maxillary sinusitis due to Haemophilus influenzae, Moraxella catarrhalis or Streptococcus pneumoniae.
- Community-Acquired Pneumonia due to Haemophilus influenzae, Mycoplasma pneumoniae, Streptococcus
pneumoniae, or Chlamydia pneumoniae - Uncomplicated skin and skin structure infections
- Duodenal ulcer due to Helicobacter pylori (combined with amoxicillin+lansoprazole)
- Clarithromycin is available as tablets, suspension and Intravenous/intramuscular injection.
- The adult dose for clarithromycin can vary between 250-400 gm depending on the type and severity of the infection and therapy last up to 14 days. Clarithromycin can be taken with or without meals.
- The dose of clarithromycin should be reduced by half in patients with severe renal impairment (CLCR 30 mL/min). When taking clarithromycin with atazanavir or ritonavir in patients with moderate or severe renal impairment, the dose of clarithromycin should be reduced by 50% or 75% for individuals with CLCR of 30 to 60 mL/min or 30 mL/min, respectively.
The majority of side effects observed in clinical trials were of a mild and transient nature. The most frequent side effects of clarithromycin are-
- Diarrhea
- Nausea
- Dyspepsia
- Abnormal taste
- Abdominal pain
- Patients with hepatic impairment and normal renal function can take clarithromycin without changing their dosage. Reduced dosage or longer dosing intervals may be recommended in the context of severe renal impairment with or without concurrent hepatic impairment.
- In patients taking clarithromycin therapy, symptoms of myasthenia gravis have worsened and new signs of myasthenic syndrome have appeared.
- In patients with a history of acute porphyria, clarithromycin in conjunction with ranitidine bismuth citrate should be avoided.
Contraindication
- Clarithromycin is contraindicated in patients with a known hypersensitivity to macrolide antibiotics such as-
- Concomitant administration of clarithromycin and any of the following drugs is contraindicated-
- Cisapride
- Pimozide
- Astemizole
- Terfenadine
- Concomitant administration of clarithromycin and colchicine is contraindicated in patients with renal or hepatic impairment.
There is no known contraindications of clarithromycin in terms of food and drinks.
Clarithromycin is contraindicated in patients with a history of cholestatic jaundice/hepatic dysfunction associated with prior use of clarithromycin.