Medicine details

ImageBedom
NameBedom
DosageSuspension
Generic NameDomperidone
Classes Central Nervous System Agent
Dopamine Antagonist / Antidopaminergic
Diseases CNS Disorder
Nausea
Vomiting
CompanyBengal Drugs & Chemical Works Pharm. Ltd.

Drug Package Details

Strength5 mg/5 ml
Storage Condition
Origin CountryBangladesh
Commercial Pack1
Price per pack28.00
Cost per pack24.64
Package unit60 ml bot
Price per unit28.00
Cost per unit24.64
Discount0
Coupon
Remarks

Domperidone

Domperidone belongs to a class of drugs called the anti emetics. It is a dopamine D2 and D3 receptor antagonist.  It speeds gastrointestinal peristalsis

Domepridone is indicated for the relief of the symptoms of nausea and vomiting

Adults and adolescents (12 years of age and older and weighing 35 kg or more): One 10mg tablet up to three times per day with maximum dose of 30 mg per day.

 

Domperidone may cause the following side effects-

  • Dry mouth
  • Anxiety
  • Somnolence
  • Headache
  • Diarrhea
  • Rash
  • Pruritus
  • Galactorrhea
  • Breast pain
  • Breast tenderness
  • Asthenia

 

  • Domperidone's elimination half-life is prolonged in patients with significant renal impairment. Dosing frequency of domperidone should be lowered to once or twice daily for recurrent administration, depending on the degree of the impairment. It's also possible that the dose will need to be lowered.
  • The drug domperidone has been linked to an increase in the QT interval on an ECG. There have been extremely few reports of QT prolongation and torsades de pointes in patients on domperidone during post-marketing surveillance. Patients with confounding risk factors, electrolyte imbalances, and concurrent medication were included in these publications, all of which could have been contributory factors.
  • Domperidone was linked to an elevated incidence of severe ventricular arrhythmias or sudden cardiac death in epidemiological investigations.

Contraindication

  • Known hypersensitivity to any component of the medication.
  • Co-administration with QT-prolonging drugs, at the exception of apomorphine, such as-
  • Co-administration with potent CYP3A4 inhibitors, such as-

 

Domperidone is contraindicated in the following situations:

  • In patients with moderate or severe hepatic impairment
  • In patients who have known existing prolongation of cardiac conduction intervals, particularly QTc, patients with significant electrolyte disturbances or underlying cardiac diseases such as congestive heart failure
  • Prolactinoma
  • When stimulation of gastric motility could be harmful e.g in patients gastro-intestinal hemorrhage, mechanical obstruction or perforation.