Medicine details
Image | |
Name | Artex |
Dosage | Tablet |
Generic Name | Artesunate |
Classes |
Antiinfective Agent Antimalarial Agent |
Diseases |
Infectious Disease Malaria |
Company | Jayson Pharmaceuticals Ltd. |
Drug Package Details
Strength | 50 mg |
Storage Condition | |
Origin Country | Bangladesh |
Commercial Pack | 12 |
Price per pack | ৳ 144.96 |
Cost per pack | ৳ 127.56 |
Package unit | 4 tabs strip |
Price per unit | ৳ 12.08 |
Cost per unit | ৳ 10.63 |
Discount | 0 |
Coupon | |
Remarks |
Artesunate
Artesunate is an antimalarial drug. Artesunate is rapidly converted into the active form DHA. Artesunate and DHA, like other artemisinins, contain an endoperoxide bridge that is activated by heme iron, resulting in oxidative stress, downregulation of protein and nucleic acid synthesis, ultrastructural changes, and a decrease in parasite survival and growth.
Artesunate for Injection is an antimalarial medication used to treat severe malaria in adults and children. Severe malaria treatment with Artesunate should always be followed by a full course of an appropriate oral antimalarial regimen.
Artesunate for Injection does not treat Plasmodium hypnozoite liver stage forms and thus does not prevent relapses of Plasmodium vivax or Plasmodium ovale malaria. Concurrent therapy with an antimalarial agent, such as an 8-aminoquinoline drug, is required for the treatment of severe malaria caused by Plasmodium vivax or Plasmodium ovale.
- The recommended dosage of Artesunate for Injection is 2.4 mg/kg given intravenously at 0 hours, 12 hours, and 24 hours, and then once daily until the patient can tolerate oral antimalarial therapy.
- Artesunate for Injection should be administered intravenously as a slow bolus over 1 to 2 minutes.
- Artesunate for Injection should NOT be given as a continuous intravenous infusion.
The most common adverse reactions reported with Artesunate include-
- acute renal failure (requiring dialysis)
- hemoglobinuria
- jaundice
- post-Treatment Hemolysis
- Hypersensitivity and anaphylaxis has been reported with artesunate injection.
- Cases of post-treatment hemolytic anemia severe enough to require transfusion have been reported. Patients should be monitored to look out for hemolytic anemia.
- Delaying treatment of severe malaria in pregnancy may result in serious morbidity and mortality to the mother and fetus
Contraindication
Known serious hypersensitivity to artesunate.
None known.
There is no known contraindications of artesunate in terms of health.