Medicine details
Image | |
Name | Trexonate 2.5 |
Dosage | Tablet |
Generic Name | Methotrexate |
Classes |
Antirheumatic Immunosuppressive Agent Antiinflammatory Agent |
Diseases |
Arthritis Cancer Leukemia Lymphoma Psoriasis |
Company | Beacon Pharmaceuticals Ltd. |
Drug Package Details
Strength | 2.5 mg |
Storage Condition | |
Origin Country | Bangladesh |
Commercial Pack | 30 |
Price per pack | ৳ 150.00 |
Cost per pack | ৳ 132.00 |
Package unit | 10 tabs strip |
Price per unit | ৳ 5.00 |
Cost per unit | ৳ 4.40 |
Discount | 0 |
Coupon | |
Remarks |
Methotrexate
Methotrexate is an antimetabolite that can treat certain cancers, psoriasis, and rheumatoid arthritis. Methotrexate inhibits the production of tetrahydrofolate, which is required for DNA, RNA & protein biosynthesis.
Methotrexate is used for the treatment of the following diseases-
Rheumatoid Arthritis (RA) including Polyarticular Juvenile Idiopathic Arthritis (PJIA):
- Adult RA: 7.5 mg once weekly.
- PJIA: 10 mg/m2 once weekly.
Psoriasis:
- Single weekly oral, intramuscular, subcutaneous, or intravenous doses of 10-25 mg.
Acute lymphoblastic leukemia
- 20mg/m2 of body size once a week.
Non-Hodgkin lymphoma:
- 2.5 milligrams (mg) twice a week. As needed and tolerated, your doctor may adjust your dose. The dose, however, is usually no more than 10 mg per week.
- Methotrexate has been linked to serious toxic reactions and even death. Patients' bone marrow, liver, lung, skin, and kidney toxicity should be closely monitored.
- Methotrexate has the potential to cause embryo-fetal toxicity, including fetal death. Use is not advised during pregnancy . Advise men and women of reproductive age to use effective contraception during and after methotrexate treatment.
- With the concomitant administration of methotrexate (usually in high doses) and some nonsteroidal anti-inflammatory drugs, unexpectedly severe (sometimes fatal) bone marrow suppression, aplastic anemia, and gastrointestinal toxicity have been reported (NSAIDs).
- Methotrexate can cause interstitial pneumonitis at any time during treatment, even at low doses. Pulmonary symptoms (particularly a dry, ineffective cough) may necessitate treatment interruption and careful investigation.
- Hepatotoxicity, fibrosis, and cirrhosis may occur after prolonged use.
- Severe, occasionally fatal, skin reactions have been reported.
- Potentially fatal opportunistic infections may occur.
- May cause impairment of fertility, oligospermia and menstrual dysfunction.
- Mistaken daily use has led to fatal toxicity.
- Patients with impaired renal function, ascites, or pleural effusions: Elimination is reduced.
- Dizziness and fatigue: May impair ability to drive or operate machinery.
Contraindication
Patients with a known Hypersensitivity to methotrexate should not receive methotrexate.
Methotrexate is contraindicated in alcoholic patients.
- Patients with psoriasis or rheumatoid arthritis with alcoholism, alcoholic liver disease or other chronic liver disease should not receive methotrexate.
- Methotrexate should not be given to patients with psoriasis or rheumatoid arthritis who have overt or laboratory evidence of immunodeficiency disorders.
- Patient with leukopenia, thrombocytopenia or significant anemia, should not receive methotrexate.
- Methotrexate is contraindicated in pregnancy and lactation.