Medicine details

ImagePredixa-16
NamePredixa-16
DosageTablet
Generic NameMethyl Prednisolone
Classes Hormonal Agent
Steroid
Glucocorticoid
Diseases Allergy
Arthritis
Asthma
Blood Disorder
Inflammatory Disease
Skin Infection
CompanyUnimed & Unihealth Manufacturers Ltd.

Drug Package Details

Strength16 mg
Storage Condition
Origin CountryBangladesh
Commercial Pack10
Price per pack240.00
Cost per pack211.20
Package unit10 tabs strip
Price per unit24.00
Cost per unit21.12
Discount0
Coupon
Remarks

Methyl Prednisolone

Methyl prednisolone belongs to a class of drugs called the glucocorticoids . Glucocorticoids are adrenocortical steroids that are quickly absorbed from the gastrointestinal tract, both naturally occurring and synthetically produced.

Methyl prednisolone is indicated in various diseases. It is indicated in-

  1. Endocrine Disorders: Primary or secondary adrenocortical insufficiency, Congenital adrenal hyperplasia, Nonsuppurative thyroiditis, Hypercalcemia associated with cancer.
  2. Rheumatic Diseases: Rheumatoid arthritis, Ankylosing spondylitis, Acute and subacute bursitis, Psoriatic arthritis, Acute gouty arthritis
  3. Collagen Disorders: Systemic lupus erythematosus, Systemic dermatomyositis, Acute rheumatic carditis etc.
  4. Dermatologic Diseases: Bullous dermatitis herpetiformis, Severe erythema multiforme, Severe psoriasis.
  5. Allergic States: Seasonal or perennial allergic rhinitis, Drug hypersensitivity reactions, Serum sickness, Contact dermatitis Bronchial asthma.
  6. Ophthalmic Diseases: Allergic corneal marginal ulcers, Herpes zoster ophthalmicus, Keratitis Optic neuritis, Allergic conjunctivitis etc.
  7. Respiratory Diseases: Symptomatic sarcoidosis, Berylliosis, Aspiration pneumonitis etc.
  8. Hematologic Disorders: Idiopathic thrombocytopenic purpura in adults, Secondary thrombocytopenia in adults, Acquired (autoimmune) hemolytic anemia etc.
  9. Neoplastic Diseases: For palliative management of -Leukemias and lymphomas in adults, Acute leukemia of childhood.
  10. Edematous States
  11. Gastrointestinal Diseases: Ulcerative colitis, Regional enteritis.
  12. Nervous System: Acute exacerbations of multiple sclerosis.
  13. Miscellaneous: Tuberculous meningitis with subarachnoid block, Trichinosis with neurologic or myocardial involvement.
  • Depending on the disease entity being treated, the first dosage of Methyl Prednisolone Tablets can range from 4 mg to 48 mg of methylprednisolone per day.
  • Lower doses are usually sufficient in less severe conditions, however higher first doses may be required in some people. The first dosage should be kept the same or increased until a good reaction is observed.
  • Methyl Prednisolone should be stopped and the patient transferred to another acceptable therapy if there is no adequate clinical response after a reasonable period of time.

THE FACT THAT DOSAGE REQUIREMENTS VARY AND MUST BE INDIVIDUALIZED BASED ON THE DISEASE UNDER TREATMENT AND THE PATIENT'S RESPONSE SHOULD BE EMPHASIZED

Methyl prednisolone can cause the following side effects-

  • Congestive heart failure in susceptible patients
  • Hypertension
  • Edema
  • Hypokalemia
  • Hypokalemic alkalosis
  • Muscle weakness
  • Loss of muscle mass
  • Steroid myopathy
  • Osteoporosis
  • Peptic ulcer with possible perforation and hemorrhage
  • Pancreatitis
  • Abdominal distention
  • Ulcerative esophagitis
  • Increased sweating
  • Development of Cushingoid state
  • Suppression of growth in children
  • Secondary adrenocortical and pituitary unresponsiveness, particularly in times of stress, as in trauma, surgery or illness
  • Menstrual irregularities
  • Decreased carbohydrate tolerance
  • Manifestations of latent diabetes mellitus

 

  • Some indications of infection may be hidden by corticosteroids, and new infections may develop as a result of their use. Infections with any pathogen, including viral, bacterial, fungal, protozoan, or helminthic infections, may be linked to the use of corticosteroids alone or in combination with other immunosuppressive agents that affect cellular immunity, humoral immunity, or neutrophil function, in any part of the body.
  • The risk of drug-induced secondary adrenocortical insufficiency can be reduced by gradually lowering the dosage. This form of relative insufficiency can last for months after you stop taking hormone therapy, therefore if you have a stressful circumstance during that time, hormone therapy should be resumed.
  • Corticosteroids have a stronger effect on hypothyroidism patients and those with cirrhosis.
  • Because of the risk of corneal perforation, corticosteroids should be taken with caution in individuals with ocular herpes simplex.
  • To regulate the condition being treated, the lowest possible amount of corticosteroid should be utilized, and when dosage reduction is possible, it should be done gradually.
  • In individuals with systemic sclerosis, caution is advised since corticosteroids, particularly methylprednisolone, have been linked to an increased risk of scleroderma renal crisis.
  • If there is a risk of impending perforation, abscess, or other pyogenic infection, steroids should be used with caution in nonspecific ulcerative colitis; diverticulitis; fresh intestinal anastomoses; active or latent peptic ulcer; renal insufficiency;
  • Infants and children receiving long-term corticosteroid medication should have their growth and development monitored closely.

Contraindication

Contraindicated in patients hypersensitive to Methyl Prednisolone or other glucocorticoids, such as-

There is no known contraindications of methyl prednisolone in terms of food and drinks.

Contraindicated in patients with systemic fungal infection.