Medicine details

ImageDepomed 40
NameDepomed 40
DosageInjection
Generic NameMethyl Prednisolone Acetate
Classes Dermatological/Topical Agent
Ophthalmic Preparation
Steroid
Diseases Allergy
Arthritis
Asthma
Blood Disorder
Inflammatory Disease
Skin Infection
CompanyDrug International Ltd.

Drug Package Details

Strength40 mg/ml
Storage Condition
Origin CountryBangladesh
Commercial Pack3
Price per pack225.75
Cost per pack198.66
Package unit1 ml vial
Price per unit75.25
Cost per unit66.22
Discount0
Coupon
Remarks

Methyl Prednisolone Acetate

Methyl Prednisolone Acetate belongs to a class of drugs, called the glucocorticoids. It is a synthetic glucocorticoid. Natural glucocorticoids (hydrocortisone and cortisone), which have salt-retaining characteristics, are employed in adrenocortical deficit replacement therapy. Their synthetic analogs are largely employed for anti-inflammatory actions in a variety of organ system illnesses.

Glucocorticoids have a wide range of metabolic consequences. Furthermore, they alter the immune system's reaction to a variety of stimuli.

  1. For Intramuscular Administration
    • Allergic States- asthma, atopic dermatitis, contact dermatitis, drug hypersensitivity reactions, seasonal or perennial allergic rhinitis, serum sickness
    • Dermatologic Diseases- Bullous dermatitis herpetiformis, exfoliative dermatitis, mycosis fungoides, pemphigus, severe erythema multiforme (Stevens-Johnson syndrome).
    • Endocrine Disorders
    • Gastrointestinal diseases: In regional enteritis (systemic therapy) and ulcerative colitis, to help the patient get through a critical time of the disease.
    • Hematologic Disorders: Acquired (autoimmune) hemolytic anemia, congenital (erythroid) hypoplastic anemia (Diamond Black fan anemia), pure red cell aplasia, select cases of secondary thrombocytopenia.
    • Neoplastic Diseases: For palliative management of: leukemias and lymphomas.
    • Nervous System: Cerebral edema associated with primary or metastatic brain tumor or craniotomy.
    • Ophthalmic Diseases: Sympathetic opthalmia, temporal arteritis, uveitis, ocular inflammatory conditions unresponsive to topical corticosteroids.
    • Renal Diseases: To induce diuresis or remission of proteinuria in idiopathic nephrotic syndrome, or that due to lupus erythematosus.
    • Respiratory Diseases: Berylliosis, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy, idiopathic eosinophilic pneumonias, symptomatic sarcoidosis.
  2. For Intra-Articular Or Soft Tissue Administration 

    • Acute gouty arthritis, acute and subacute bursitis, acute nonspecific tenosynovitis, epicondylitis, rheumatoid arthritis, synovitis of osteoarthritis.
  3. For Intralesional Administration

    • alopecia areata, discoid lupus erythematosus; keloids, localized hypertrophic, infiltrated inflammatory lesions of granuloma annulare, lichen planus, lichen simplex chronicus (neurodermatitis) and psoriatic plaques; necrobiosis lipoidica diabeticorum.

Methyl prednisolone acetate Sterile Aqueous Suspension should not be diluted or mixed with other solutions due to probable physical incompatibilities.

  • The initial dose of Methyl prednisolone acetate given via parenteral administration will range from 4 to 120 mg, depending on the disease entity being treated. In certain overwhelming, urgent, life-threatening conditions, however, delivery in quantities greater than the typical dosages may be warranted, and these dosages may be multiples of the regular dosages.

Cardiovascular: Bradycardia, cardiac arrest, cardiac arrhythmias, cardiac enlargement, circulatory collapse, congestive heart failure, fat embolism, hypertension etc.

Dermatologic: Acne, allergic dermatitis, cutaneous and subcutaneous atrophy, dry scaly skin, ecchymoses and petechiae, edema, erythema, hyperpigmentation, hypopigmentation, impaired wound healing etc.

Endocrine: Decreased carbohydrate and glucose tolerance, development of cushingoid state, glycosuria, hirsutism, hypertrichosis, increased requirements for insulin or oral hypoglycemic agents in diabetes.

Gastrointestinal: Abdominal distention, bowel/bladder dysfunction (after intrathecal administration), elevation in serum liver enzyme levels (usually reversible upon discontinuation), hepatomegaly, increased appetite, nausea, pancreatitis.

Musculoskeletal: Aseptic necrosis of femoral and humeral heads, calcinosis (following intra-articular or intra-lesional use), Charcot-like arthropathy, loss of muscle mass, muscle weakness, osteoporosis.

Neurologic/Psychiatric: Convulsions, depression, emotional instability, euphoria, headache, increased intracranial pressure with papilledema (pseudotumor cerebri) usually following discontinuation of treatment, insomnia.

 

  • The injection of corticosteroids into the epidural space has been linked to serious neurologic events, some of which have resulted in death.
  • When applied locally to neural tissue, this substance contains benzyl alcohol, which can be harmful.
  • To avoid contamination, use Methyl prednisolone acetate Sterile Aqueous Suspension in several doses from a single vial. Despite being sterile at first, any multidose use of vials might lead to contamination if proper aseptic technique is not followed. It's important to take extra precautions, such as using disposable sterilized syringes and needles.
  • Corticosteroids, in both little and large dosages, can raise blood pressure, promote salt and water retention, and cause potassium excretion to increase.
  • Corticosteroids can produce reversible Hypothalamic-pituitary adrenal  axis suppression with the potential for glucocorticosteroid insufficiency after withdrawal of treatment.
  • Latent disease may be activated or there may be an exacerbation of intercurrent infections due to pathogens, including those caused by Amoeba, Candida, Cryptococcus, Mycobacterium, Nocardia, Pneumocystis, and Toxoplasma.
  • Patients on corticosteroids are more susceptible to infections than healthy people.
    Corticosteroids should not be used in the presence of systemic fungal infections unless they are required to control medication responses.
  • In individuals receiving immunosuppressive doses of corticosteroids, live or live-attenuated vaccines are contraindicated. Vaccines that have been killed or inactivated may be used. The reaction to such immunizations, however, cannot be predicted.

Contraindication

  • Contraindicated in patients hypersensitive to Methyl Prednisolone acetate or other glucocorticoids, such as-
  • Vaccine receiving patients should not receive Methyl Prednisolone acetate.

There is no known contraindications of methyl prednisolone in terms of food and drinks.

Contraindicated in patients with systemic fungal infection.