Rifaximin is indicated for the following conditions-

• Traveller's diarrhea (causes by Escherichia coli)
• Reduction in risk of overt Hepatic encephalopathy 
•  Irritable bowel syndrome with diarrhea

Traveler's Diarrhea

Hepatic Encephalopathy

Travelers’ diarrhea

• One 200 mg tablet taken orally three times a day for 3 days, with or without food.

Hepatic encephalopathy

• One 550 mg tablet taken orally two times a day, with or without food.

Irritable bowel syndrome with diarrhea

• One 550 mg tablet 3 times a day for 14 days. Patients who experience recurrence can be retreated up to two times with the same regimen.

Commonly associated adverse reactions in travelers’ diarrhea:

• Flatulence
• headache
• abdominal pain
• rectal tenesmus
• defecation urgency
• nausea

Commonly associated adverse reactions in Hepatic encephalopathy:

• Peripheral edema
• nausea
• dizziness
• fatigue
• ascites

Flatulence	Headache	Nausea
Edema	Dizziness	Fatigue

• Diarrhea caused by bacteria other than E. coli: Rifaximin was ineffective in diarrhea complicated by fever and/or blood in the stool, as well as diarrhea caused by pathogens other than E. coli.
• Discontinue Rifaximin and consider other medicines if diarrhea symptoms worsen or last longer than 24 hours.
• Diarrhea caused by Clostridium difficile: Determine if diarrhea occurs after treatment, or if it improves or worsens during treatment.
• In individuals with severe hepatic impairment (Child-Pugh C), use with caution.
• When rifaximin and a P-glycoprotein inhibitor are used together, caution should be used.