Medicine details

ImageAsmaloc 400 SR
NameAsmaloc 400 SR
DosageTablet
Generic NameTheophylline
Classes Respiratory Agent
Antiasthmatic
Methylxanthines
Diseases Asthma
Bronchitis
Emphysema
Respiratory Disease
CompanySharif Pharmaceuticals Ltd.

Drug Package Details

Strength400 mg
Storage Condition
Origin CountryBangladesh
Commercial Pack50
Price per pack149.00
Cost per pack131.12
Package unit10 tabs strip
Price per unit2.98
Cost per unit2.62
Discount0
Coupon
Remarks

Theophylline

Theophylline is a bronchodilator. Additionally, it has an impact on a variety of cells that are implicated in the inflammatory processes linked to asthma and chronic obstructive pulmonary disease. Increased suppressor T-lymphocyte activity and a decline in neutrophil and eosinophil activity may be of greatest significance. These actions may help prevent inflammation in asthma and chronic obstructive pulmonary disease. Theophylline blocks phosphodiesterase, an enzyme responsible for the degradation of cAMP in bronchial cells. As a result, it causes bronchial smooth muscle relaxation.

 

  • Theophylline is indicated for the treatment and prophylaxis of bronchospasm associated with asthma, chronic obstructive pulmonary disease and chronic bronchitis. It is also indicated for the treatment of left ventricular and congestive cardiac failure.
  • Theophylline should not be used as first drug of choice in the treatment of asthma in children.

 

  • Adults and the elderly: The typical maintenance dose is 200 mg every 12 hours. Depending on the therapeutic response, this can be increased to 300 mg or 400 mg.
  • Pediatric population aged 6 years and above: The usual pediatric maintenance dose is 9 mg/kg twice daily. Some children with chronic asthma require and tolerate much higher doses (10-16 mg/kg twice daily).

 

Theophylline is a well tolerated drug. But following side effects may occur in some patients-

  • abdominal pain
  • chest pain or discomfort
  • fainting
  • arrythmia
  • lightheadedness
  • vomiting
  • palpitations
  • seizures
  • dizziness
  • Due to decreases metabolism of theophylline, dose modification and monitoring of plasma theophylline concentrations may be required in elderly patients and patients with-
    • cardiac disease
    • hepatic disease
    • exacerbations of lung disease
    • hypothyroidism
    • fever
    • viral infections
  • The patient's response to therapy should be closely monitored; worsening asthma symptoms requires medical attention.
  • In patients with severe hypertension or chronic alcoholism, use with caution.
  • Because theophylline may aggravate cardiac arrhythmias, it should be used with caution in patients with cardiac disorders.

 

 

Contraindication

  • Theophylline is contraindicated in patients with hypersensitivity to xanthines such as-
  • Concomitant administration with ephedrine in children less than 6 years of age (or less than 22 kg).

 

 

  • Contraindicated in patients with porphyria.
  • Theophylline is contraindicated in children under 6 months of age.