Name | Rocuronium Bromide |
Classes |
Central Nervous System Agent Muscle Relaxant Neuromuscular Blocker |
Diseases |
Anesthesia Mechanical Ventilation Tracheal Intubation |
Rocuronium Bromide
Rocuronium Bromide is a nondepolarizing neuromuscular blocking agent with all of the pharmacological actions associated with this class of drugs (curariform). It works by vying for cholinergic receptors on the motor end-plate. Anticholinesterase agents such as pyridostigmine, neostigmine, and edrophonium inhibit acetylcholine antagonism and reverse neuromuscular block.
Rocuronium Bromide injection is used as a supplement to general anesthesia to help with tracheal intubation and to relax skeletal muscles during surgery or mechanical ventilation.
- To be administered only by experienced clinicians or adequately trained individuals supervised by an experienced clinician familiar with the use, actions, characteristics, and complications of neuromuscular blocking agents.
- Individualize the dose for each patient.
- Peripheral nerve stimulator recommended for determination of drug response and need for additional doses, and to evaluate recovery.
- Tracheal intubation: Recommended initial dose is 0.6 mg/kg
- Rapid sequence intubation: 0.6 to 1.2 mg/kg
- Maintenance doses: Guided by response to prior dose, not administered until recovery is evident.
- Continuous infusion: Initial rate of 10 to 12 mcg/kg/min. Start only after early evidence of spontaneous recovery from an intubating dose.
The following side effects may occur with the use of Rocuronium-
- Salivation
- Rashes
- Bronchospasm
- Flushing
- Hypotension
- Tachycardia
- Appropriate Administration and Monitoring: Use only if facilities for intubation, mechanical ventilation, oxygen therapy, and an antagonist are immediately available.
- Anaphylaxis: Severe anaphylaxis has been reported. Consider cross-reactivity among neuromuscular blocking agents.
- Need for Adequate Anesthesia: Must be accompanied by adequate anesthesia or sedation.
- Residual Paralysis: Consider using a reversal agent in cases where residual paralysis is more likely to occur.
Contraindication
Contraindicated in patients with Hypersensitivity (e.g., anaphylaxis) to rocuronium bromide or other neuromuscular blocking agents such as-
None known.
None known.