Name Sulfaclozine
Classes Antiinfective Agent
Antiprotozoal / Amebicide
Diseases Cholera
Coccidiosis
Fowl Typhoid
Veterinary Infection

Sulfaclozine

In protozoa and bacteria, Sulfaclozine is a competitive antagonist of para-aminobenzoic acid (PABA), a precursor of folic acid. Sulfaclozine is commonly used for the treatment of various poultry diseases (particularly, collibacteriosis, fowl cholera and coccidiosis)

It is indicated for treatment of 

  • coccidiosis in poultry due to infection with Eimeria species
  • Fowl typhoid due to infection with Salmonella gallinarum 
  • Fowl cholera due to infection with Pasteurella multocida.
  • Poultry: Dissolve 1g Sulfaclozine (Sulfachloropyrazine) sodium monohydrate 30% per liter water. This provides approximately 50 mg active ingredient, or 170 mg Sulfaclozine (Sulfachloropyrazine) sodium monohydrate, per kg bodyweight. 
  • Treat for 3 consecutive days and repeat after a 2 days break if necessary (Shuttle programs like day 1, 3, 5, 7, 9 or 1, 2, 5, 6, 9 have also been found effective). · 
  • For coccidiosis in chicken caused by E. tenella and E. necatrix doses of 1.5g to 2.0g are indicated (75-100 g in 50 liters of drinking water). · 
  • For the treatment of cholera and typhoid, doses of 1 to 2 g Sulfaclozine (Sulfachloropyrazine) sodium monohydrate per liter water for at least 5 days are required. Sheep and Goats: 120 mg Sulfaclozine per kg body weight (Dissolve a full sachet in 1 liter drinking water and administer 12 ml for each 10kg Body weight).

Side effects include-

  • Liver damage
  • Allergic reactions
  • First aider needs to protect himself. Move out of the dangerous area. Take off all contaminated clothing immediately.
  • Inhalation:Remove to fresh air. If respiratory problems develop, obtain medical attention.
  • Skin contact:After contact with skin, wash immediately with plenty of water. If skin irritation persists, call a physician.
  • Eye contact:Rinse immediately with plenty of water, also under the eyelids. If eye irritation persists, consult a specialist.
  • Ingestion:Rinse mouth with water. Do not induce vomiting without medical advice. Never give anything by mouth to an unconscious person. 
  • If symptoms persist, call a physician.

Contraindication

Contraindicated in-

  • Anticonvulsants, hydantoin
  • Antidiabetic agents
  • Bone marrow depressants
  • Cyclosporine 
  • Methenamine

There's no known contraindications of the drug in terms of food and drinks.

There's no known contraindications of the drug in terms of health.