• For the treatment of
  Uncomplicated urinary tract infections due to Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Enterobacter Species, S. saprophyticus.

UTI (Urinary Tract Infection)

• The usual oral adult dosage is 100 mg of trimethoprim every 12 hours or 200 mg of trimethoprim every 24 hours, each for 10 days.
• The use of trimethoprim in patients with a creatinine clearance of less than 15 mL/min is not recommended.
• For patients with a creatinine clearance of 15 to 30 mL/min, the dose should be 50 mg every 12 hours.

The most reported adverse reactions regardless of causality, in patients treated with Trimethoprim were:

• Rash
• Pruritus
• Phototoxic skin eruptions.
• Hyperkalemia
• Hyponatremia.

Rash

Photosensitivity

Hyperkalemia (High Potassium)

Hyponatremia

• In the absence of a proven or strongly suspected bacterial infection or a preventive rationale, prescribing trimethoprim tablets, USP is unlikely to benefit the patient and increases the chance of drug-resistant bacteria developing.
• Trimethoprim should be used with caution in people who may be deficient in folate. Folates can be taken together with trimethoprim without interfering with its antibacterial properties.
• Patients with poor renal or hepatic function should be given trimethoprim with caution.
• The problem of diarrhea is very prevalent. Antibiotics are to blame, when the antibiotic is finished, it usually ends and has been phased out. Occasionally, following Antibiotics will be used to begin treatment. Watery and swollen eyes are common in patients (with and without) bloody stools even if you have stomach cramps and a fever two or more months after the event after finishing the final dose of the medication antibiotic. Patients may be affected if this occurs one should seek medical advice as soon as possible immediately.