Dorzolamide is indicated for the-

• reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma

Glaucoma

Occular hypertension

• The dose is one drop of Brinzolamide in the affected eye(s) two times daily.
• If more than one topical ophthalmic drug is being used, the drugs should be administered at least five minutes apart

How to administer eye drops:

Eye Drops

Commonly associated side effects include-

• eye burning
• eye stinging
• eye redness
• blurred vision
• eye tearing
• eye itching

Ocular burning/ Eye burning

Eye redness

Excessive Tearing

Eye Irritation

• In addition to ocular hypotensive medications, individuals with acute angle-closure glaucoma require treatment approaches. In individuals with acute angle closure glaucoma, Brinzolamide has not been examined.
• Patients with severe renal impairment (CrCl 30 mL/min) have not been investigated with Brinzolamide. Brinzolamide and its metabolite are primarily eliminated through the kidneys, hence Brinzolamide is not advised in these patients.
• Brinzolamide has not been tested in patients with hepatic impairment, so it should be used with caution in these individuals.
• Local ocular side effects, notably conjunctivitis and lid responses, have been described with continuous Brinzolamide treatment in clinical investigations. Many of these symptoms resembled an allergic reaction in appearance and course, and they all went away when the drugs were stopped. If such responses occur, Brinzolamide should be stopped and the patient assessed before restarting the medication.
• In patients receiving an oral carbonic anhydrase inhibitor and Brinzolamide, there is the possibility of an additive effect on the known systemic effects of carbonic anhydrase inhibition. It is not recommended to take Brinzolamide and oral carbonic anhydrase inhibitors at the same time.
• There is an increased potential for developing corneal edema in patients with low endothelial cell counts. Precautions should be used when prescribing Brinzolamide to this group of patients.