Amitriptyline + Chlordiazepoxide is indicated for the relief of symptoms of anxiety and depression associated with various mental and mood disorders.

Depression

Anxiety

• Amitriptyline + Chlordiazepoxide Tablets are available as blue, film-coated, biconvex tablets containing 5 mg chlordiazepoxide and 12.5 mg amitriptyline (as the hydrochloride salt)
• Amitriptyline + Chlordiazepoxide Tablets in an initial dosage of 3 or 4 tablets daily in divided doses may be satisfactory in patients who do not tolerate higher doses. 

The most common adverse reactions associated with Amitriptyline + Chlordiazepoxide include:

• Drowsiness
• Dry mouth
• Dizziness
• Constipation
• Blurred vision
• Urinary retention
• Anorexia
• Sexual dysfunction
• Confusion
• Headache
• Nausea and vomiting
• Skin rash

Drowsiness	Dry Mouth	Dizziness
Constipation	Blurred vision	Anorexia

Before initiating treatment with Amitriptyline + Chlordiazepoxide, the following warnings and precautions should be considered:

• Suicidal thoughts or behavior: This medication may increase the risk of suicidal thinking and behavior, especially in children, adolescents, and young adults.
• Serotonin syndrome: This medication may cause serotonin syndrome, a potentially life-threatening condition characterized by mental status changes, autonomic instability, neuromuscular abnormalities, and gastrointestinal symptoms.
• CNS depression: This medication may cause CNS depression, which can impair the ability to perform tasks that require mental alertness or physical coordination, such as driving or operating machinery.
• Respiratory depression: This medication may cause respiratory depression, especially in patients with compromised respiratory function or concurrent use of other CNS depressants.
• Anticholinergic effects: This medication may cause anticholinergic effects, such as dry mouth, blurred vision, constipation, and urinary retention.
• Interactions: This medication may interact with other drugs that affect the CNS, such as alcohol, sedatives, and opioids.
• Hyperpyretic crises, severe convulsions and deaths have occurred in patients receiving a tricyclic antidepressant and a monoamine oxidase inhibitor simultaneously.  When it is desired to replace a monoamine oxidase inhibitor with Amitriptyline + Chlordiazepoxide, a minimum of 14 days should be allowed to elapse after the former is discontinued.