Name Brimonidine Tartrate + Timolol Maleate
Classes Dermatological/Topical Agent
Ophthalmic Preparation
Glaucoma Agent
Diseases Glaucoma
IOP-Lowering Therapy
Ophthalmic Disease

Brimonidine Tartrate + Timolol Maleate

Brimonidine tartrate + timolol maleate is a combination medication of an alpha-2 adrenergic receptor agonist (brimonidine tartrate) and a beta-adrenergic receptor antagonist (timolol maleate). It is an ophthalmic solution used to lower intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.

 

Brimonidine tartrate + timolol maleate is indicated for the treatment of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.

 

The usual recommended dose of brimonidine tartrate + timolol maleate is one drop in the affected eye(s) twice daily, approximately 12 hours apart. It should be used as directed by a physician.

 

The most common adverse reactions include:

  • Ocular hyperemia
  • Ocular allergic reactions (including itching, burning, stinging)
  • Somnolence
  • Headache
  • Conjunctivitis
  • Corneal erosion
  • Hypertension
  • Dry mouth
  • Blurred vision
  • Eye discharge

 

  • Brimonidine tartrate + timolol maleate is not recommended for patients with bronchial asthma, a history of bronchial asthma, severe chronic obstructive pulmonary disease, sinus bradycardia, second or third-degree atrioventricular block, overt cardiac failure, cardiogenic shock, or hypersensitivity to any component of this medication.
  • Caution should be exercised when using brimonidine tartrate + timolol maleate in patients with severe cardiovascular disease, depression, cerebrovascular insufficiency, Raynaud's phenomenon, orthostatic hypotension, or thromboangiitis obliterans.
  • Brimonidine tartrate + timolol maleate may cause respiratory and cardiac reactions, including bronchospasm and cardiac failure, in patients with chronic obstructive pulmonary disease (COPD), asthma, or congestive heart failure.
  • Patients should be advised not to drive or operate machinery until they know how brimonidine tartrate + timolol maleate affects them.
  • Use of this medication may result in decreased mental alertness and impaired physical ability.

 

Contraindication

Brimonidine Tartrate + Timolol Maleate is contraindicated in-

  • Patients hypersensitive to any component of the formulation
  • Patients receiving monoamine oxidase (MAO) inhibitor therapy, tricyclic antidepressants such as-
  • Patients on antidepressants which affect noradrenergic transmission such as-
    • Mianserin

 

Brimonidine Tartrate + Timolol Maleate is contraindicated in-.

  • Reactive airway disease including bronchial asthma 
  • asthma, severe chronic obstructive pulmonary disease.
  • Sinus bradycardia, sick sinus syndrome sino-atrial block, second or third degree
  • atrioventricular block not controlled with a pace-maker, overt cardiac failure
  • cardiogenic shock
  • Use in neonates and infants (less than 2 years of age)