| Name | Colistin Sulphate + Trimethoprim |
| Classes |
Antiinfective Agent Antibiotic Antibiotic Combination |
| Diseases |
Bordetella E. coli Infection Pertusis Staphylococcus Infection Veterinary Infection |
Bangla
EnglishColistin Sulphate + Trimethoprim
Colistin Sulphate + Trimethoprim is a combination antibiotic drug for veterinary use. Colistin Sulphate is a cyclic polypeptide antibiotic that disrupts the bacterial cell membrane, causing the leakage of cellular components and ultimately leading to bacterial death. Trimethoprim is a diaminopyrimidine antibiotic that inhibits bacterial folate synthesis, resulting in the suppression of bacterial growth and replication.
Colistin Sulphate + Trimethoprim is indicated for the treatment of bacterial infections in animals caused by susceptible organisms. It is commonly used for the treatment of respiratory, gastrointestinal, and urinary tract infections in animals.
- Lambs : Twice daily 1 dose per 2.5 - 3 kg body weight for 3 days.
Piglets (1 - 3 kg) : Daily 1 dose, for 3 days.
Piglets (3 - 5 kg) : Twice daily 1 dose for 3 days. - Each press on the dosing pump delivers one dose, i.e. 1 ml.
- Withdrawal period - For meat: 7 days.
The following side effects may be caused by Colistin Sulphate + Trimethoprim-
- renal dysfunction
- neurotoxicity and neuromuscular blockade.
- The use of Colistin Sulphate + Trimethoprim should be avoided in animals with known hypersensitivity to the drug or its components.
- Use with caution in animals with impaired kidney function.
- The drug should not be used in pregnant or lactating animals, as the safety of the drug has not been established in these groups.
- Do not use in food-producing animals.
- Avoid handling the drug if allergic reactions occur.
Contraindication
Colistin Sulphate + Trimethoprim is contraindicated in animals with known hypersensitivity to the drug or its components.
None known.
None known.