Name Dextrose + Sodium Chloride
Classes Electrolyte and Mineral
Nutritional Supplement
Diseases Electrolytic Imbalance
Fluid Loss

Dextrose + Sodium Chloride

5% Dextrose and 0.45% Sodium Chloride Injection, USP solution is sterile and nonpyrogenic. It is a large volume parenteral solution containing dextrose and sodium chloride in water for injection intended for intravenous administration.

Dextrose + Sodium Chloride Injection, USP is indicated as a source of water and calories.

  • The dose is determined by the patient's age, weight, and clinical condition.
  • Because of the increased risk of hyperglycemia/hypoglycemia in pediatric patients, especially newborns and low birth weight infants, the dosage and steady infusion rate of intravenous dextrose must be chosen with prudence, according to the literature.
  • Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit

Side effects are rare and are related to injection-

  • Phlebitis
  • Pain at injection site
  • Dextrose Anhydrous + Sodium Chloride Injection, USP should not be administered simultaneously with blood through the same administration set because of the possibility of pseudo-agglutination or hemolysis.
  • The intravenous administration of these solutions can cause fluid and/or solute overloading resulting in dilution of serum electrolyte concentrations, overhydration, congested states, or pulmonary edema.
  • The risk of dilutive states is inversely proportional to the electrolyte concentrations of the injections.
  • The risk of solute overload causing congested states with peripheral and pulmonary edema is directly proportional to the electrolyte concentrations of the injections.
  • Excessive administration of dextrose injections may result in significant hypokalemia. In very low birth weight infants, excessive or rapid administration of dextrose injection may result in increased serum osmolality and possible intracerebral hemorrhage.

Contraindication

Solutions containing dextrose may be contraindicated in patients with known allergy to corn or corn products.