| Name | Gentamicin + Sulphadimidine + Trimethoprim |
| Classes |
Antiinfective Agent Lubricant and Irrigants |
| Diseases |
Bangla
EnglishGentamicin + Sulphadimidine + Trimethoprim
Gentamicin + Sulphadimidine + Trimethoprim is a combination antibiotic drug consisting of gentamicin, an aminoglycoside antibiotic, sulphadimidine, a sulfonamide antibiotic, and trimethoprim, a diaminopyrimidine antibiotic. The combination of these three drugs provides a broad-spectrum antibiotic effect against gram-negative and some gram-positive bacteria. The mechanism of action of gentamicin involves inhibiting protein synthesis in bacterial cells, while sulphadimidine and trimethoprim block the folic acid synthesis pathway, which is essential for bacterial cell growth.
- Calves, lambs and kid-goats less than 3 months old – treatment of animals suffering from pasteurellosis, mycoplasmosis, dysentery, salmonellosis, pneumonia caused by organisms sensitive to the components of the preparation.
- Pigs – treatment of animals suffering from dysentery, pneumonia, erysipelas, colibacillosis, salmonellosis, pasteurellosis caused by microorganisms sensitive to the components of the preparation.
- Dogs, cats – treatment of animals with diseases of the respiratory and alimentary canals caused by organisms sensitive to the components of the preparation.
- Hens Broilers, Turkeys – treatment of birds sick with salmonellosis, pasteurellosis, and respiratory diseases caused by microorganisms sensitive to the components of the preparation.
- The antibiotic preparation is to be administered orally.
- Calves – 1 g of the preparation per 10 kg of body weight;
- Lambs and kid-goats – 1 g of the preparation per 10 kg of body weight;
- Pigs – 1 g of the preparation per 10 kg of body weight;
- Dogs, cats – 1 g of the preparation per 10 kg of body weight;
- Poultry (chicken-broilers, turkeys) – 1 g of the preparation per 2.5 – 2.8 kg of feed.
- The preparation is used with the intervals 24 hours, treatment course 3 – 5 days.
The common adverse reactions associated with the use of Gentamicin + Sulphadimidine + Trimethoprim in animals include:
- Allergic reactions, such as skin rash, hives, and anaphylaxis
- Gastrointestinal disturbances, such as vomiting and diarrhea
- Kidney damage and nephrotoxicity
- Ototoxicity, especially in cats
- Hematological disorders, such as anemia and leukopenia
- Hypersensitivity reactions, such as fever, lethargy, and depression.
- Gentamicin + Sulphadimidine + Trimethoprim should be used with caution in animals with pre-existing renal, hepatic, or hematological disorders.
- The drug should not be administered to animals with a known hypersensitivity to any of its components.
- Concurrent administration with other nephrotoxic or ototoxic drugs, such as aminoglycosides or loop diuretics, should be avoided.
- The drug should not be used in pregnant or lactating animals, as it may harm the fetus or newborns.
- The drug should be used only under the supervision of a veterinarian, and the instructions for use should be strictly followed.
Contraindication
- Gentamicin + Sulphadimidine + Trimethoprim is contraindicated in animals with a history of hypersensitivity to any of its components.
- Do not use simultaneously with other aminoglycosides and antibiotics with nephrotoxic effect (polymyxin B, colistin, amphotercin, chloramphenicol, cephalospirin, erythromycin).
None known.
- Do not use for animals in lactating period and animals with impaired renal function, hearing and balance.
- Do not administer to laying hens producing eggs for human consumption.
- Do not use for treatment of hunting and service dogs, in connection with a possible lesion vestibular and hearing.