Name Hydrochlorothiazide + Losartan Potassium
Classes Cardiovascular Agent
Antihypertensive
Antihypertensive Combination
Diseases Cardiovascular Disease
Hypertension (High Blood Pressure)

Hydrochlorothiazide + Losartan Potassium

Hydrochlorothiazide + Losartan Potassium is a combination of losartan potassium an orally active, AT1 receptor subtype specific angiotensin II receptor blocker (ARB), and hydrochlorothiazide, a diuretic.

Hydrochlorothiazide + Losartan Potassium is used to treat the following conditions-

  • Hypertension
  • Hypertensive patients with left ventricular hypertrophy

Hypertension:

  • Losartan potassium and hydrochlorothiazide are used in patients whose blood pressure is not controlled sufficiently by losartan potassium or hydrochlorothiazide alone.
  • The usual starting dose of losartan 50 mg/hydrochlorothiazide 12.5 mg once daily. The dosage can be increased after 3 weeks of therapy to a maximum of 100/25 (losartan 100 mg/hydrochlorothiazide 25 mg) once daily as needed to control blood pressure
  • For haemodialysis patients, losartan and hydrochlorothiazide pills are not indicated. Patients with significant renal impairment should not take losartan/HCTZ tablets.

The side effects associated with the medication are as follows-

  • headache
  • dizziness
  • Pharyngitis
  • Hypotension
  • Tinnitus
  • Dyspepsia
  • Asthenia
  • During the second and third trimesters of pregnancy, medications that act on the renin-angiotensin system impair fetal renal function and increase fetal and newborn morbidity and death.
  • Symptomatic hypotension can occur in patients with an active renin-angiotensin system, such as volume- and/or salt-depleted patients on high doses of diuretics.
  • Patients whose renal function may depend in part on the activity of the renin-angiotensin system (e.g., patients with renal artery stenosis, chronic kidney disease, severe congestive heart failure, or volume depletion) may be at particular risk of developing acute renal failure on Hydrochlorothiazide + Losartan Potassium.

Contraindication

  •  Contraindicated to the patients who are sensitive to hydrochlorothiazide or to other sulfonamide-derived drugs, such as-
  • Contraindicated to the patients who are sensitive to Losartan potassium or other ARBs, such as-
  • Concomitant use of Hydrochlorothiazide + losartan potassium with aliskiren containing products in patients with diabetes mellitus or renal impairment.
  • Hydrochlorothiazide +Losartan potassium is contraindicated in pregnancy.
  • Hydrochlorothiazide +Losartan potassium is contraindicated in patients with severe kidney problems (GFR 30 mL/min) and anuria due to the hydrochlorothiazide component.
  • Hydrochlorothiazide + Losartan potassium is contraindicated in patients with significant hepatic problems or biliary cirrhosis and cholestasis due to the Telmisartan component.