| Name | Timolol Maleate + Travoprost |
| Classes |
Dermatological/Topical Agent Ophthalmic Preparation Glaucoma Agent |
| Diseases |
Glaucoma Ophthalmic Disease |
Bangla
EnglishTimolol Maleate + Travoprost
Timolol Maleate + Travoprost is an ophthalmic preparation. Timolol is a beta adrenoceptor antagonist and Latanoprost is a prostaglandin analogue. Timolol reduces the rate of aqueous humor formation through reduction of blood flow to the ciliary process. Latanoprost reduces the intraocular pressure (IOP) by increasing the outflow of aqueous humor.
Timolol Maleate + Travoprost indicated in adults (including the elderly) for the reduction of intraocular pressure (IOP) in patients with open angle glaucoma and ocular hypertension who are insufficiently responsive to topical beta-blockers or prostaglandin analogues.
Adults
- One eye drop in the affected eye(s) once daily is recommended as therapy. It should be taken at the same time every day.
- If a dose is missed, treatment should resume with the next scheduled dose. The dose should not be more than one drop in the affected eye(s) per day.
| Administering eye drop |
The following side effects were reported-
- Iris hyperpigmentation
- Eye pain
- Eye burning
- Eye irritation
- Foreign body sensation
- Conjunctivitis
- Blepharitis
- Excessive tearing
- Timolol Maleate + Travoprost like other topically applied ophthalmic agents, is systemically absorbed. The beta-adrenergic component timolol may cause the same types of cardiovascular, pulmonary, and other adverse reactions as systemic beta-adrenergic blocking agents.
- In patients with cardiovascular diseases (e.g., coronary heart disease, Prinzmetal's angina, and cardiac failure) and hypotension, beta-blocker therapy should be evaluated critically, and other active substances should be considered.
- Patients with severe peripheral circulatory disturbances/disorders (for example, severe Raynaud's disease or Raynaud's syndrome) should be treated with caution.
- Ophthalmic beta-blockers may cause eye dryness. Patients suffering from corneal diseases should be treated with extreme caution.
- Some ophthalmic beta-blockers have been associated with respiratory reactions, including death due to bronchospasm in asthma patients. In patients with mild/moderate chronic obstructive pulmonary disease (COPD), Timolol Maleate + Travoprost should be used with caution and only if the potential benefit outweighs the potential risk.
- Following filtration procedures, aqueous suppressant therapy (e.g., timolol, acetazolamide) has been associated with choroidal detachment.
Contraindication
Contraindicated in patients with hypersensitivity to the active substances or to any of the excipients.
None known.
Contraindicated in-
- Reactive airway disease including bronchial asthma or a history of bronchial asthma, severe chronic obstructive pulmonary disease.
- Sinus bradycardia, sick sinus syndrome, sinoatrial block, second or third degree atrioventricular block not controlled with pace-maker, overt cardiac failure, cardiogenic shock.
