Carvedilol is indicated in the following diseases-

• Hypertension
• Heart failure
• Angina pectoris

Hypertension (Hight Blood Pressure)

Heart Failure

Angina

Hypertension:

Adults: For the first two days, a dose of 12.5 mg once a day is advised. The medication is then continued at a daily dose of 25 mg. If necessary, the dose can be gradually increased at two-week intervals or more infrequently.

Elderly: For hypertension, the suggested beginning dose is 12.5 mg once a day, which may be sufficient for long-term treatment. If the therapeutic response is insufficient at this dose, the dose may be gradually increased at two-week intervals or more infrequently.

Angina pectoris:

A twice-daily regimen is recommended.

Heart failure:

For the first two weeks, take 3.125 mg twice a day. If this dose is tolerated, it can be gradually increased to 6.25 mg twice a day, then 12.5 mg twice a day, and eventually 25 mg (max.) twice a day, with intervals of not less than two weeks. The dosage should be adjusted to the maximum level that can be tolerated.

Side effects commonly associated with carvedilol include-

• Dizziness
• headache
• Bronchitis, pneumonia, upper respiratory tract infection, urinary tract infection
• Anaemia
• Weight increase
• hypercholesterolaemia
• hyperglycaemia
• Depression
• Dry eye
• Cardiac failure

Dizziness	Anemia	Bronchitis	Headache
Dry Eye	Heart Failure	Hyperglycemia	Weight Gain

• In chronic heart failure patients carvedilol should be administered principally in addition to diuretics, ACE inhibitors, digitalis and/or vasodilators.
• In heart failure patients with low blood pressure (systolic 100 mm Hg), ischemic heart disease, widespread atherosclerosis, and/or underlying renal insufficiency, reversible impairment of renal function has been observed after carvedilol medication.
• Carvedilol should be used with caution in patients with chronic heart failure who are taking digitalis, because both digitalis and carvedilol extend the AV conduction time.