NameCeftriaxone
Classes Anti-infective Agent
Antibiotic
Cephalosporine
Diseases Bone Infection
Bronchitis
Gonorrhea
Infectious Disease
Meningitis
Otitis
Pelvic Inflammatory Disease (PID)
Pneumonia
Sinusitis
Tonsillitis
Urethritis

Ceftriaxone

Ceftriaxone is a broad-spectrum parenteral cephalosporin antibiotic of the third generation. It has strong bactericidal properties against both Gram-positive and Gram-negative bacteria.

Ceftriaxone is indicated for the following infections causes by susceptible strains-

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery
  • Lyme disease

Ceftriaxone is only available as intravenous and intramuscular injection. The usual dose for adults is 1-2 gm per day.

The common side effects of ceftriaxone are-

  • Nausea
  • Vomiting
  • Diarrhea
  • Eosinophilia
  • Thrombocytosis

 

  • Hypersensitivity reaction & Anaphylactic shock may occur, in such cases immediate clinical attention is required.
  • Severe cases of hemolytic anemia, including fatalities in adults and children, have been reported.
  • Interaction with Calcium-containing Products: Precipitation can occur. Do not administer simultaneously with calcium-containing IV solutions.
  • Patients with both hepatic and renal impairment should not received more than 2 grams of ceftriaxone per day.

Contraindication

Contraindicated in patients hypersensitive to any beta lactam antibiotics such as-

Ceftriaxone is contraindicated in newborns under 28 days.