Cilastatin is used in combination with imipenem to treat a variety of bacterial infections, including intra-abdominal, gynecological, skin, and respiratory tract infections caused by susceptible organisms.

Bacterial Infection

Abdominal Infection

Skin Infection

Respiratory infections

The dosage and administration of cilastatin should be determined by the severity of the infection and the patient's renal function. The usual dose of cilastatin is 500 mg administered intravenously every 6 hours in combination with imipenem.

The following adverse reactions have been reported with the use of cilastatin:

• Diarrhea
• Nausea and vomiting
• Rash
• Hypersensitivity reactions, including anaphylaxis
• Elevated liver enzymes
• Renal dysfunction

Diarrhea

Nausea

Rash

Kidney Problem

• Cilastatin should be used with caution in patients with renal impairment.
• Cilastatin should be discontinued immediately if hypersensitivity reactions occur.
• Cilastatin should not be used in patients with a history of anaphylaxis to any beta-lactam antibiotic.
• The concomitant use of cilastatin with probenecid may increase the plasma concentration of cilastatin.
• Cilastatin should be used with caution in patients with hepatic impairment.
• Cilastatin should be used with caution in pregnant or lactating women.