Name Cinnarizine
Classes Central Nervous System Agent
Diseases CNS Disorder
Motion Sickness
Nausea
Tinnitus (Ear Buzzing)
Vertigo
Vomiting

Cinnarizine

Cinnarizine belongs to the class of drugs known as calcium channel blockers with antihistaminic properties. Its exact mechanism of action is not fully understood, but it is thought to inhibit the entry of calcium ions into smooth muscle cells and block histamine H1 receptors. This action helps to reduce the constriction of blood vessels and suppress the effects of histamine, leading to its therapeutic effects.

 

Cinnarizine is indicated for the treatment of the following conditions:

  • Vertigo and balance disorders: It is used to relieve symptoms of vertigo, dizziness, and balance disorders associated with conditions such as Ménière's disease and vestibular disorders.
  • Motion sickness: Cinnarizine is effective in preventing and treating symptoms of motion sickness, including nausea, vomiting, and dizziness.

 

The dosage of cinnarizine may vary depending on the individual's condition and response to treatment. It is typically administered orally as tablets. The dosage and frequency of administration should be determined by a healthcare professional based on the specific indication and the patient's age and weight.

 

The following side effects may occur with cinnarizine-

  • Drowsiness
  • Dry mouth
  • Gastrointestinal disturbances (such as stomach pain, nausea, and vomiting)
  • Increased appetite and weight gain
  • Headache
  • Fatigue
  • Allergic reactions (rare)

 

  • Sedation: Cinnarizine may cause drowsiness and impair mental alertness. Patients should exercise caution when driving or operating machinery until they know how the medication affects them.
  • Use in the elderly: Elderly patients may be more susceptible to the sedative effects of cinnarizine. The dosage should be adjusted accordingly.
  • Hepatic impairment: Cinnarizine is metabolized by the liver, and caution should be exercised when prescribing to patients with severe liver dysfunction.
  • Pregnancy and breastfeeding: Cinnarizine should be used with caution during pregnancy and breastfeeding. The potential risks and benefits should be discussed with a healthcare professional.

 

Contraindication

Cinnarizine is contraindicated in individuals with known hypersensitivity to cinnarizine or any of the product's components.