Colistin Sulphate is indicated for the treatment of bacterial infections in veterinary animals caused by susceptible strains of Gram-negative bacteria, particularly when other less toxic antimicrobial agents are not effective.

Veterinary Infection

Dosage may vary based on the specific indication, patient species, and severity of the infection.

• • Administered intramuscularly or intravenously.
  • Dosage based on the weight and condition of the animal.
  • Adjust the dose according to the severity of the infection.

Broiler, Layer, Shonali, and Breeder chicken: 1ml of colistin sulfate dissolved in 2-4 liter of water and treated for 3-5 days.

Cattle, Goat, Calf, and sheep: 1mL/40 kg body weight b.i.d for 3-5 days. 

Adverse reactions are listed from most common to least common:

• Nephrotoxicity
• Neurotoxicity
• Ototoxicity
• Hypersensitivity reactions
• Neuromuscular blockade (rare)

Nephrotoxicity

Ototoxicity

Hypersensitivity

• Renal Function Monitoring: Regularly monitor renal function in veterinary patients, especially in those with pre-existing renal impairment. Adjust dosage based on individual animal characteristics.
• Neurological Monitoring: Observe for signs of neurotoxicity, such as ataxia or muscle weakness. Adjust dosage if neurotoxicity occurs.
• Hearing Function Monitoring: Regularly assess hearing function, especially in animals receiving prolonged therapy. Discontinue Colistin Sulphate if signs of ototoxicity occur.
• Neuromuscular Blockade: Use with caution in animals receiving neuromuscular blocking agents, as Colistin Sulphate may enhance neuromuscular blockade.
• Allergic Reactions: Monitor for hypersensitivity reactions, including rash and pruritus. Discontinue Colistin Sulphate if allergic reactions occur.
• Superinfection: Prolonged use may result in overgrowth of nonsusceptible organisms. Institute appropriate measures if superinfection occurs.