| Name | Dantrolene Sodium |
| Classes |
Central Nervous System Agent Muscle Relaxant Skeletal Muscle Relaxant |
| Diseases |
Cerebral Palsy CNS Disorder Hyperthermia (High Body Temperature) Sclerosis Spinal Cord Injury Stiffness Stroke |
Bangla
EnglishDantrolene Sodium
Dantrolene Sodium belongs to the class of direct-acting skeletal muscle relaxants. Its mechanism of action involves blocking the release of calcium from the sarcoplasmic reticulum in muscle cells, thus reducing muscle contraction. Dantrolene is primarily used to prevent or treat malignant hyperthermia and to manage muscle spasticity.
Dantrolene Sodium is indicated for the following:
- Malignant Hyperthermia (MH): As an adjunct to general anesthesia to prevent and treat the development of malignant hyperthermia.
- Muscle Spasticity: For the management of chronic spasticity associated with various neurological conditions, such as spinal cord injury, stroke, and multiple sclerosis.
Each patient's dose should be gradually adjusted to reach the necessary individual dosage. It is advisable to prescribe the lowest dose that achieves the desired response for each patient. The suggested dosage escalation schedule is provided below.
Dantrolene sodium should be titrated at a rate no faster than outlined in the following timetable:
|
Week 1: Week 2: Week 3: Week 4: |
25 mg once a day 25 mg two times a day 50 mg two times a day 50 mg three times a day |
However, doses above 200 mg per day should not be given for more than 2 months.
Paediatric Population
Dosing table for children over 5 years (upwards of 25 kg body weight) For the individual patient the lowest dose compatible with optimal response is recommended. A recommended dosage titration schedule is provided below.
|
Week 1: Week 2: Week 3: Week 4: Week 5: Week 6: |
1 Dantrium 25mg capsule once a day 1 Dantrium 25mg capsule two times a day 1 Dantrium 25mg capsule three times a day 2 Dantrium 25mg capsules two times a day 2 Dantrium 25mg capsules three times a day 3 Dantrium 25mg capsules three times a day |
Adverse reactions associated with Dantrolene are listed from most common to least common:
- Muscle weakness
- Drowsiness
- Dizziness
- Fatigue
- Diarrhea
- Nausea
- Hepatotoxicity (rare)
- Hepatotoxicity: Monitor liver function regularly, especially in patients on prolonged therapy.
- Respiratory Depression: Use with caution in patients with pre-existing respiratory conditions. Monitor respiratory function closely.
- Oral Dose Conversion: When switching from intravenous to oral therapy, the dose conversion ratio may vary. Carefully calculate the equivalent oral dose.
Contraindication
Contraindicated in patients with Hypersensitivity to the active substance or any of the excipients.
Contraindicated in patients with Wheat allergy.
Contraindicated in patients with-
- Hepatic disorders
- Impaired respiratory function
- Severe impaired cardiac function due to myocardial disease
- In cases where abnormally increased tone is required to allow better function, an upright posture or balance during movement
- Pregnancy and breastfeeding
- Coeliac diseases)
