Name Aluminium Chloride Hexahydrate
Classes Dermatological/Topical Agent
Diseases Excessive Sweating (Hyperhidrosis)
Skin Disorder

Aluminium Chloride Hexahydrate

Aluminium Chloride Hexahydrate is classified as an antiperspirant and an astringent when used dermatologically. Its mechanism of action involves blocking the sweat ducts in the eccrine glands, leading to a reduction in the production of sweat. Aluminium Chloride acts by forming complexes with proteins in the sweat ducts, resulting in the formation of plugs that inhibit the flow of sweat to the skin surface.

Aluminium Chloride Hexahydrate is indicated for the topical treatment of hyperhidrosis (excessive sweating) in specific localized areas, such as the axillae (underarms), palms, and soles. It is commonly used when other measures, such as over-the-counter antiperspirants, have proven ineffective.

Dosage recommendations may vary based on the specific area being treated and the severity of hyperhidrosis.

  1. Axillae (Underarms):

    • Apply a thin layer of Aluminium Chloride Hexahydrate solution or gel to the affected area once daily, typically at bedtime.
    • Wash off the product in the morning.
  2. Palms and Soles:

    • Apply the solution or gel sparingly to the palms or soles once daily, preferably at bedtime.
    • Wash off the product in the morning.

Adverse reactions are listed from most common to least common:

  • Local irritation (redness, itching, burning sensation)
  • Dryness of the skin
  • Temporary discoloration of the skin
  • Allergic contact dermatitis
  • Formation of papules or pustules
  • Skin Sensitivity: Aluminium Chloride Hexahydrate may cause skin irritation, especially in individuals with sensitive skin. Discontinue use if severe irritation occurs.
  • Discoloration: Temporary skin discoloration may occur, especially in individuals with darker skin tones. This is usually reversible upon discontinuation.
  • Avoid Mucous Membranes: Avoid contact with mucous membranes, eyes, and open wounds. Rinse thoroughly if accidental contact occurs.
  • Pregnancy and Lactation: Limited data are available on the use of Aluminium Chloride Hexahydrate during pregnancy and lactation. Consult a healthcare professional before use.
  • Children: The safety and efficacy of Aluminium Chloride Hexahydrate in children have not been well established. Use with caution and under medical supervision.

Contraindication

Aluminium Chloride Hexahydrate is contraindicated in individuals with known hypersensitivity or allergy to aluminium chloride hexahydrate or any component of the formulation.

Aluminium Chloride Hexahydrate is contraindicated in individuals with renal impairment or kidney disease.