Name Gadoversetamide
Classes Diagnostic Agent
Radiologic Agent
Diseases Imaging
MRI

Gadoversetamide

Gadoversetamide is a Gadolinium-based contrast agent. Gadoversetamide enhances the visibility of internal structures during MRI by altering the magnetic properties of nearby hydrogen nuclei.

Gadoversetamide indicated for intravenous use: 

  • In patients with an abnormal blood-brain barrier or abnormal vascularity of the brain, spine, and associated tissues.
  • To provide contrast enhancement and facilitate visualization of lesions with abnormal vascularity in the liver in patients who are highly suspect for liver structural abnormalities on computed tomography.
  • Bolus peripheral intravenous injection at a dose of 0.2 mL/kg (0.1 mmol/kg) 
  • Follow injection with a 5 mL normal saline flush. 
  • Complete imaging procedure within 1 hour of injection.

Most common adverse reactions (incidence >2%) are: headache, vasodilatation, taste perversion, dizziness, nausea and paresthesia.

  • Nephrogenic Systemic Fibrosis (NSF) has occurred in patients with impaired elimination of Gadolinium Based Contrast Agents (GBCAs). Higher than recommended dosing or repeat dosing appears to increase the risk.
  • Acute Kidney Injury (AKI) has occurred in patients with preexisting renal insufficiency. Use the lowest necessary dose of Gadoversetamide in these patients.
  • Hypersensitivity reactions including fatal reactions have occurred, particularly in patients with history of allergy, drug reactions, or other hypersensitivity like disorders. Monitor these patients closely during and after administration of Gadoversetamide.
  • Interference with laboratory measurements of serum iron, copper and zinc and in the measurement of serum calcium using the ortho-cresophthalin complexone (OCP) colorimetric method has occurred. 

Contraindication

 Contraindicated in patients with prior hypersensitivity reactions to gadolinium, versetamide, or any of the inert ingredients. 

Gadoversetamide is contraindicated in-

  • Chronic, severe kidney disease (glomerular filtration rate, GFR <30 mL/min/1.73m2)
  • acute kidney injury