Amiloride is indicated in the following health conditions-

• Edema
• Hypertension
• Hypokalemia

Edema

Hypertension (Hight Blood Pressure)

• Amiloride is available as tablets.
• Amiloride HCl should be taken after a meal.
• Amiloride HCl, one 5 mg tablet daily, should be added to a kaliuretic diuretic's normal antihypertensive or diuretic dosage. If necessary, the dosage can be increased to 10 mg per day. Amiloride HCl doses of more than two 5 mg tablets per day are normally unnecessary, and there is limited controlled experience with higher doses.

Side effects associated (incidence >1%) with amiloride include-

• Headache
• Weakness and fatigue (asthenia)
• Nausea
• Diarrhea
• Abdominal pain
• Dizziness
• Cough
• Dyspnea

Headache

Asthenia

Nausea

Dizziness

Patients who are-

• elderly
• at risk of developing acidosis
• have diabetes mellitus
• have compromised hepatic
• renal function

should be given amiloride with caution.

• Patients with compromised renal function, as well as very unwell patients with ascites and metabolic alkalosis, or those with resistant oedema who are also taking diuretics, should have their serum electrolytes and blood urea levels closely examined.
• Hyperkalemia can occur in patients who use amiloride alone or in combination with other diuretics or angiotensin-converting enzyme inhibitors.