Gramacidin is indicated for the treatment of infections caused by susceptible strains of Gram-negative bacteria. It is commonly used for topical applications in conditions such as skin and eye infections.

Bacterial Infection

Skin Infection

Eye Infection

Dosage and administration of Gramacidin depend on the specific formulation and the type and severity of the infection. It is generally applied topically to the affected area, following the recommended guidelines provided by the healthcare provider.

Common adverse reactions associated with the use of Gramacidin may include:

• Local irritation at the application site
• Allergic dermatitis
• Itching or burning sensation
• Redness or swelling
• Skin rash

Irritation

Dermatitis

Itching

Physicians should be aware of the following warnings and precautions when prescribing Gramacidin:

• Neurotoxicity: Systemic absorption of Gramacidin may lead to neurotoxic effects, especially with prolonged use or in patients with compromised renal function. Monitor patients for signs of neurotoxicity, such as dizziness, vertigo, and muscle weakness.

• Allergic Reactions: Patients may develop allergic reactions, including severe dermatitis. Discontinue use if signs of allergy occur and institute appropriate therapy.

• Photosensitivity: Gramacidin may cause increased sensitivity to sunlight. Advise patients to protect treated areas from direct sunlight to minimize the risk of photosensitivity reactions.

• Pregnancy and Lactation: Use Gramacidin with caution in pregnant or lactating women, considering the potential risks and benefits.