Amoxicillin is indicated for the following diseases-

• Infections of the Ear, Nose, and Throat
• Infections of the Genitourinary Tract
• Infections of the Skin and Skin Structure
• Infections of the Lower Respiratory Tract
• Helicobacter pylori Infection

Pharyngitis

UTI (Urinary Tract Infection)

Respiratory infections

Adult: 250 mg three times daily, increasing up to 500 mg three times daily for severe infections.

Children (up to 10 years of age) : 125 mg three times daily, increasing up to 250 mg three times daily for severe infections.

• Severe or recurrent purulent respiratory infection: 3 gm every 12 hours.
• Otitis media: Recommended dose is 1 g three times daily for adult and 40 mg/kg body weight daily in 3 divided doses for children (max. 3 g daily).
• Pneumonia: Recommended dose is 500-1000 mg three times daily.
• Dental abscess: Recommended dose is 3 gm, repeated after 10-12 hours.
• Urinary tract infections: Recommended dose is 3 gm, repeated after 10-12 hours.
• Gonorrhoea: Single dose of 2-3 gm with Probenecid 1 gm is recommended (Probenecid is contraindicated in children under 2 years).
• In renal impairment: it may be necessary to reduce the total daily dosage.

The side effects of amoxicillin trihydrate is usually mild. The most common side effects is Clostridium difficile associated diarrhea. Incidents of rash have also been reported. A rare but serious side effect is hypersensitivity reaction.

Some patients may show hypersensitivity reactions to ampicillin trihydrate. In such cases treatment should be stopped immediately. Superinfection of resistant organisms like C.difficile may occur.