| Name | Amphotericin B |
| Classes |
Antiinfective Agent Antifungal Agent |
| Diseases |
Breathing Difficulty Disfiguring Infectious Disease Lesions Nose Bleed Skin Sore |
Bangla
EnglishAmphotericin B
Amphotericin B is a polyene macrolide antifungal agent administered intravenously as infusions. It binds to the ergosterol molecule and makes artificial pore in the fungal cell wall through which cell contents spill out which kills the fungi.
Amphotericin B is used t treat the following infections-
Amphotericin B should be administered by intravenous infusion, using a controlled infusion device, over a period of approximately 120 minutes. An in-line membrane filter may be used for the intravenous infusion of Amphotericin B; provided THE MEAN PORE DIAMETER OF THE FILTER IS NOT LESS THAN 1.0 MICRON.
An existing intravenous line must be flushed with 5% Dextrose Injection prior to infusion of Amphotericin B. If this is not feasible, Amphotericin B must be administered through a separate line.
| Indication | Dose |
| Empirical therapy | 3 mg/kg |
| Systemic fungal infections: Aspergillus Candida Cryptococcus |
3-5 mg/kg |
| Cryptococcal meningitis in HIV infected patients |
6 mg/kg |
The drug should be administered by medically trained personnel. During the initial dosing period, patients should be under close clinical observation.
Contraindication
Amphotericin B is contraindicated in those patients who have known hypersensitivity to amphotericin B or any other constituents of the product unless, in the opinion of the treating physician, the benefit of therapy outweighs the risk.
There is no known contraindication of amphotericin B on terms of food and drinks.
Amphotericin B is contraindicated to anyone who have previously shown hypersensitivity reaction to the drug or any of its components.