Loteprednol etabonate is indicated for the treatment of inflammation and pain associated with ocular surgery, allergic conjunctivitis, and other inflammatory eye conditions.

Eye inflammation

Conjunctivitis

Loteprednol etabonate ophthalmic suspension:

• One to two drops four times per day beginning 24 hours after surgery and continuing throughout the post-operative period.
• Treatment should not last more than two weeks.

Eye Drops

Loteprednol etabonate ophthalmic gel: 

• Before instilling drops, invert the closed bottle and shake once to fill the tip.
• Apply one to two drops of loteprednol to the conjunctival sac of the affected eye four times daily beginning the day after surgery and continuing for the first two weeks.

Eye Gel

The most common adverse drug reactions were-

• anterior chamber inflammation
• eye pain 
• foreign body sensation 
• eye burning
• dry eye

Eye inflammation

Dry Eye

Ocular burning/ Eye burning

• Patients using Loteprednol etabonate should be monitored for signs of increased intraocular pressure, especially if they have a history of glaucoma. If intraocular pressure increases, the medication should be discontinued or the dose should be decreased.
• Loteprednol etabonate should be used with caution in patients with a history of herpes simplex virus, as it can exacerbate the condition. It should also be used with caution in patients with cataracts or diabetes, as it can increase the risk of these conditions.
• The medication should not be used for longer than necessary, as prolonged use can lead to complications such as cataracts or glaucoma.
• Fungal infections of the cornea are especially likely to develop in conjunction with long-term local steroid application. In any persistent corneal ulceration where a steroid has been or is being used, fungus invasion must be considered.
• Prolonged corticosteroid use may suppress the host response, increasing the risk of secondary ocular infection. Steroids may mask or exacerbate infection in acute purulent conditions.
• Steroid use after cataract surgery may delay healing and increase the likelihood of bleb formation. In those diseases causing thinning of the cornea or sclera, perforations have been known to occur with the use of topical steroids.