6-Aminopenicillanic Acid is indicated for the treatment of bacterial infections caused by susceptible microorganisms. It may be used in various infections, including respiratory tract infections, skin and soft tissue infections, urinary tract infections, and other conditions where bacterial pathogens are susceptible to its antibacterial activity.

Respiratory infections

Skin Infection

UTI (Urinary Tract Infection)

• Dosage may vary based on the specific infection, severity, and patient age.
• The recommended dosage is determined by the healthcare provider based on the type and severity of the infection. Typically administered orally or through injection.

Adverse reactions associated with 6-APA include-

• Hypersensitivity reactions (e.g., rash, itching, anaphylaxis)
• Gastrointestinal disturbances (e.g., nausea, vomiting, diarrhea)
• Superinfections (e.g., fungal or bacterial overgrowth)
• Hematologic effects (e.g., leukopenia, thrombocytopenia)
• Neurological effects (e.g., seizures in high doses)

Hypersensitivity

Nausea

Diarrhea

Leukopenia

• Hypersensitivity: Monitor patients for signs of hypersensitivity reactions, especially those with a history of penicillin allergy. Discontinue use if an allergic reaction occurs and initiate appropriate medical therapy.
• Clostridium difficile-associated Diarrhea (CDAD): Consider CDAD in patients presenting with diarrhea after antibiotic use. Discontinue treatment if CDAD is suspected or confirmed and initiate appropriate therapy.
• Superinfections: Prolonged use may result in overgrowth of nonsusceptible organisms, including fungi. Monitor patients for superinfections and institute appropriate therapy if necessary.
• Hematologic Effects: Monitor complete blood counts regularly, especially in patients with pre-existing hematologic conditions or those on prolonged treatment.
• Neurological Effects: Use with caution in patients with a history of seizures or central nervous system disorders. Seizures have been reported in patients treated with high doses of beta-lactam antibiotics.