Brimonidine tartrate + timolol maleate is indicated for the treatment of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.

Elevated IOP (Intra Occular Pressure)

Open Angle Glaucoma

The usual recommended dose of brimonidine tartrate + timolol maleate is one drop in the affected eye(s) twice daily, approximately 12 hours apart. It should be used as directed by a physician.

The most common adverse reactions include:

• Ocular hyperemia
• Ocular allergic reactions (including itching, burning, stinging)
• Somnolence
• Headache
• Conjunctivitis
• Corneal erosion
• Hypertension
• Dry mouth
• Blurred vision
• Eye discharge

Conjunctival Hyperemia

Conjunctivitis

Dry Mouth

Hypertension (High Blood Pressure)

• Brimonidine tartrate + timolol maleate is not recommended for patients with bronchial asthma, a history of bronchial asthma, severe chronic obstructive pulmonary disease, sinus bradycardia, second or third-degree atrioventricular block, overt cardiac failure, cardiogenic shock, or hypersensitivity to any component of this medication.
• Caution should be exercised when using brimonidine tartrate + timolol maleate in patients with severe cardiovascular disease, depression, cerebrovascular insufficiency, Raynaud's phenomenon, orthostatic hypotension, or thromboangiitis obliterans.
• Brimonidine tartrate + timolol maleate may cause respiratory and cardiac reactions, including bronchospasm and cardiac failure, in patients with chronic obstructive pulmonary disease (COPD), asthma, or congestive heart failure.
• Patients should be advised not to drive or operate machinery until they know how brimonidine tartrate + timolol maleate affects them.
• Use of this medication may result in decreased mental alertness and impaired physical ability.