Medicine details
Image | |
Name | Disys S PLUS 80/12.5 |
Dosage | Tablet |
Generic Name | Hydrochlorothiazide + Valsartan |
Classes |
Cardiovascular Agent Antihypertensive Antihypertensive Combination |
Diseases |
Cardiovascular Disease Hypertension (High Blood Pressure) |
Company | Healthcare Pharmaceuticals Ltd. |
Drug Package Details
Strength | 12.5 mg + 80 mg |
Storage Condition | |
Origin Country | Bangladesh |
Commercial Pack | 30 |
Price per pack | ৳ 300.00 |
Cost per pack | ৳ 264.00 |
Package unit | 6 tabs strip |
Price per unit | ৳ 10.00 |
Cost per unit | ৳ 8.80 |
Discount | 0 |
Coupon | |
Remarks |
Hydrochlorothiazide + Valsartan
Hydrochlorothiazide + Valsartan is a combination of valsartan, an orally active, AT1 receptor subtype specific angiotensin II receptor blocker (ARB), and hydrochlorothiazide, a diuretic.
This combination is used to treat Hypertension.
- Hydrochlorothiazide + Valsartan is available as tablets.
- Hydrochlorothiazide + Valsartan 160/12.5 mg once day is the usual beginning dose. After 1 to 2 weeks of therapy, the dosage can be increased to a maximum of one 320/25 tablet once day as needed to regulate blood pressure. After a dosage modification, the maximum antihypertensive effects are achieved in 2 to 4 weeks.
The side effects associated with the medication are as follows-
- headache
- dizziness
- Pharyngitis
- Hypotension
- Tinnitus
- Dyspepesia
- Asthenia
- During the second and third trimesters of pregnancy, medications that act on the renin-angiotensin system impair fetal renal function and increase fetal and newborn morbidity and death.
- In controlled trials, patients with uncomplicated hypertension treated with Hydrochlorothiazide + Valsartan experienced a very little (0.7 percent) drop in blood pressure. Symptomatic hypotension can occur in patients with an active renin-angiotensin system, such as volume- and/or salt-depleted patients on high doses of diuretics.
Contraindication
- Contraindicated to the patients who are sensitive to hydrochlorothiazide or to other sulfonamide-derived drugs, such as-
- Contraindicated to the patients who are sensitive to valsartan or other ARBs, such as-
- Concomitant use of Hydrochlorothiazide + Valsartan with aliskiren containing products in patients with diabetes mellitus or renal impairment.
- Hydrochlorothiazide + Valsartan is contraindicated in pregnancy.
- Hydrochlorothiazide + Valsartan is contraindicated in patients with severe kidney problems (GFR 30 mL/min) and anuria due to the hydrochlorothiazide component.
- Hydrochlorothiazide + Valsartan is contraindicated in patients with significant hepatic problems or biliary cirrhosis and cholestasis due to the valsartan component.