Medicine details
| Image |  |
| Name | Omesil IR |
| Dosage | Capsule |
| Generic Name | Omeprazole + Sodium Bicarbonate |
| Classes |
Antiulcerants Antiulcerant Combination |
| Diseases |
Peptic Ulcer GERD (Gastroesophageal Reflux Disease) Duodenal Ulcer Gastric Ulcer Gastric and Duodenal Ulcer |
| Company | Silva Pharmaceuticals Ltd. |
Drug Package Details
| Strength | 20 mg + 1100 mg |
| Storage Condition | |
| Origin Country | Bangladesh |
| Commercial Pack | 60 |
| Price per pack | ৳ 240.00 |
| Cost per pack | ৳ 211.20 |
| Package unit | 4 caps strip |
| Price per unit | ৳ 4.00 |
| Cost per unit | ৳ 3.52 |
| Discount | 0 |
| Coupon | |
| Remarks |
Omeprazole + Sodium Bicarbonate
Omeprazole and sodium bicarbonate combination is used to treat certain conditions where there is too much acid in the stomach. Omeprazole is a proton pump inhibitor (PPI). It works by decreasing the amount of acid produced by the stomach.
The combination medication is used to treat-
- Short-term treatment of active duodenal ulcer
- Short-term treatment of active benign gastric ulcer
- Treatment of gastroesophageal reflux disease (GERD)
- Maintenance of healing of erosive esophagitis
- Reduction of risk of upper GI bleeding in critically ill patients
| Indication | Recommended dose | Frequency |
| Short-Term Treatment of Active Duodenal Ulcer | 20 mg | Once daily for 4 weeks* |
| Benign Gastric Ulcer | 40 mg | Once daily for 4-8 weeks |
| Symptomatic GERD (with no esophageal erosions) | 20 mg | Once daily for up to 4 weeks |
| Erosive Esophagitis | 20 mg | Once daily |
| Maintenance of Healing of Erosive Esophagitis | 20 mg | Once daily |
| Reduction of Risk of Upper Gastrointestinal Bleeding in Critically Ill Patients (40 mg oral suspension only) | 40 mg | 40 mg initially followed by 40 mg 6-8 hours later and 40 mg daily thereafter for 14 days |
* Most patients heal within 4 weeks. Some patients may require an additional 4 weeks therapy.
How to reconstitute omeprazole-sodium bicarbonate suspension:
- Concomitant Gastric Malignancy: Symptomatic response to therapy with Omeprazole + Sodium bicarbonate does not preclude the presence of gastric malignancy.
- Atrophic gastritis has been noted occasionally in gastric corpus biopsies from patients treated long-term with Omeprazole + Sodium bicarbonate.
- Omeprazole + Sodium bicarbonate therapy may be associated with an increased risk of Clostridium difficile associated diarrhea, especially in hospitalized patients. This diagnosis should be considered for diarrhea that does not improve.
- Omeprazole + Sodium bicarbonate therapy may be associated with an increased risk for osteoporosis-related fractures of the hip, wrist, or spine. The risk of fracture was increased in patients who received high-dose, defined as multiple daily doses, and long-term PPI therapy (a year or longer).
- The metabolism of clopidogrel to its active metabolite can be impaired by use with concomitant medications, such as Omeprazole + Sodium bicarbonate, that interfere with CYP2C19 activity.
- Hypomagnesemia, symptomatic and asymptomatic, has been reported rarely in patients treated with PPIs for at least three months, in most cases after a year of therapy
- Concomitant use of PPIs with methotrexate may elevate and prolong serum levels of methotrexate and/or its metabolite, possibly leading to methotrexate toxicities.
Contraindication
Tell your doctor if you are taking the following medications as they may affect the omeprazole and sodium biocarbonate activity.
There is no know food or drink which can affect this combination. But if you are taking any vitamins, food supplements, or herbal products, please talk to your pharmacist/doctor.
There is no known contraindications of omeprazole + sodium bicarbonate in terms of health and conditions.
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