Rifampicin is indicated for the following conditions-

• Tuberculosis
• Treatment of asymptomatic carriers of Neisseria meningitidis.

TB (Tuberculosis)

Tuberculosis

• Adults: 10 mg/kg in a single daily dose not to exceed 600 mg/day, orally or intravenously.
• Pediatric patients: 10-20 mg/kg, not to exceed 600 mg/day, oral or IV. 
• Oral rifampin should be taken once a day, either one hour before or two hours after a meal, with a full glass of water.

Meningococcal Carriers

• Adults: It is suggested that individuals take 600 mg of rifampin twice daily for two days.
• Pediatric patients 1 month of age or older: For two days, take 10 mg/kg (maximum 600 mg per dosage) every 12 hours.
• Pediatric patients under 1 month of age: For two days, take 5 mg/kg every 12 hours.

Gastrointestinal: Heartburn, epigastric distress, anorexia, nausea, vomiting, jaundice, flatulence, cramps, and diarrhea.

Hepatic: Liver dysfunction, Hepatitis.

Hematologic: Thrombocytopenia.

CNS disorders: Headache, Drowsiness, Dizziness, Asthenia.

Acidity	Anorexia	Nausea
Liver problems	Headache	Dizziness

• The drug rifampin has been linked to liver damage. Patients with liver illness and those taking rifampin with other hepatotoxic medications have died as a result of jaundice.
• In patients with a history of diabetes mellitus, rifampin should be administered with caution since diabetes management may be more challenging.
• Rifampin has enzyme induction properties, which means it can speed up the metabolism of endogenous substrates such adrenal hormones, thyroid hormones, and vitamin D. Vitamin D metabolism has been observed to be affected by rifampin and isoniazid.
• Rifampin causes a reddish-orange to reddish-brown color change in urine, saliva, sputum, perspiration, teeth, and tears. This is to be expected when taking this medication.