Demeclocycline Hydrochloride is indicated for the treatment of certain bacterial infections caused by susceptible strains, including:

• Respiratory tract infections
• Urinary tract infections
• Skin and soft tissue infections
• Sexually transmitted infections

Respiratory infections

UTI (Urinary Tract Infection)

Skin Infection

Sexually Transmitted Infection

• Adults: Usual daily dose - Four divided doses of 150 mg each or two divided doses of 300 mg each.
• For pediatric patients above eight years of age: Usual daily dose, 7 to 13 mg per kg body weight per day, depending upon the severity of the disease, divided into two to four doses not to exceed adult dosage of 600 mg per day.
• Gonorrhea patients sensitive to penicillin may be treated with demeclocycline administered as an initial oral dose of 600 mg followed by 300 mg every 12 hours for four days to a total of 3 grams. 

The following side effects have been reported with Demeclocycline Hydrochloride-

• Gastrointestinal disturbances (nausea, vomiting, diarrhea)
• Photosensitivity reactions (increased sensitivity to sunlight)
• Skin reactions (rash, itching)
• Headache
• Dizziness
• Tooth discoloration (in children)
• Vaginal candidiasis (yeast infection)
• Hepatotoxicity (liver damage)
• Blood disorders (anemia, thrombocytopenia)

Diarrhea

Photosensitivity

Teeth discoloration

Liver problems

• Allergic reactions: Discontinue the use of Demeclocycline Hydrochloride and seek medical attention if signs of an allergic reaction (rash, swelling, difficulty breathing) occur.
• Photosensitivity: Avoid excessive sunlight or artificial UV light exposure during treatment as Demeclocycline Hydrochloride may increase the risk of sunburn. Use protective clothing and sunscreen.
• Superinfection: Prolonged or repeated use may result in the overgrowth of non-susceptible bacteria or fungi. If a secondary infection occurs, appropriate measures should be taken.
• Renal impairment: Use with caution in patients with renal impairment as dose adjustment may be necessary.
• Hepatic impairment: Use with caution in patients with liver dysfunction as Demeclocycline Hydrochloride may cause hepatotoxicity.
• Pregnancy and breastfeeding: Use of Demeclocycline Hydrochloride during pregnancy or breastfeeding should be done only if clearly needed and under the guidance of a healthcare professional.