Itraconazole is indicated for the treatment of the following fungal infections when thought likely to be susceptible:

• Vulvovaginal candidiasis
• Pityriasis versicolor
• Dermatophytoses caused by organisms susceptible to itraconazole (Trichophyton spp. Microsporum spp. Epidermophyton floccosum) e.g. tinea pedis, tinea cruris, tinea corporis, tinea manuum.
• Oral and systemic candidiasis.
• Onychomycosis caused by dermatophytes and/or yeasts.

Vaginal Candidiasis

pityriasis versicolor

Candidiasis

Onychomycosis

Itraconazole can cause the following side effects-

• Abdominal pain
• nausea
• Rash
• Headache
• dizziness
• diarrhoea
• dyspepsia
• Taste disturbances
• Edema
• Liver problems (rare)
• Thrombocytopenia

Rash	Taste disturbances	Dyspepsia
Thrombocytopenia	Edema	Dizziness

• A transient asymptomatic decrease in left ventricular ejection fraction was seen in a healthy volunteer study with intravenous itraconazole; this reversed before the following infusion.
• If the benefit clearly outweighs the danger, itraconazole should be given in individuals with congestive heart failure or a history of congestive heart failure.
• In patients with a history of hepatic dysfunction, the value of hepatic enzymes should be evaluated. It should also be done on a regular basis in all patients who have been on continuous treatment for more than one month, or whenever a patient exhibits signs and symptoms of liver dysfunction.