| Name | Nicorandil |
| Classes |
Cardiovascular Agent Vasodilator Antianginal Agent |
| Diseases |
Angina Cardiovascular Disease |
Bangla
EnglishNicorandil
Nicorandil is a potassium channel opener and nitrate drug that belongs to the class of anti-anginal agents. It works by dilating the coronary arteries and increasing blood flow to the heart, thereby reducing the workload on the heart and improving oxygen supply to the heart muscles.
Nicorandil is indicated for the prevention and treatment of angina pectoris, a condition characterized by chest pain or discomfort due to reduced blood flow to the heart muscles. It is also used in the treatment of chronic stable angina and variant angina.
The usual therapeutic range is 10 to 20 mg twice daily. The usual starting dose is 10 mg twice daily (bid), in the morning and in the evening preferably. It is recommended that the dose be titrated upwards in accordance with the patient's needs, response and tolerance up to 40 mg twice daily, if necessary. A lower starting dose of 5 mg twice daily may be used in patients particularly prone to headache.
- Females should use effective contraception.
- Monitor patients for atrial fibrillation.
- Monitor heart rate decreases and bradycardia symptoms during treatment.
- Not recommended in patients with 2nd degree AV block.
Contraindication
- Nicorandil is contraindicated in patients hypersensitive to any component of the formulation.
- In combination with strong cytochrome CYP3A4 inhibitors such as-
None known.
Nicorandil is contraindicated in the following conditions-
- Acute decompensated heart failure
- Clinically significant hypotension
- Sick sinus syndrome, sinoatrial block or 3rd degree AV block, unless a functioning demand pacemaker is present
- Clinically significant bradycardia
- Severe hepatic impairment
- Heart rate maintained exclusively by the pacemaker
