It is intended for the treatment of

• urinary tract infections
• acute otitis media in pediatric patients (when clinically indicated)
• acute exacerbations of chronic bronchitis in adults\
• enteritis caused by susceptible Shigella
• prophylaxis and treatment of Pneumocystis jiroveci pneumonia, and travelers' diarrhea caused by enterotoxigenic E. coli

UTI (Urinary Tract Infection)

Otitis

Bronchitis

Gastrointestinal Infection

Sulfamethoxazole is often used in combination with trimethoprim. It is not usually used as a monotherapy.

Sulfamethoxazole with TMP double strength tablet: Over 12 years

• For mild to moderate infections: 1 tablet twice daily.
• For severe infections: 1.5 tablets twice daily.
• Long term therapy (>14 days): 0.5 tablet twice daily.
• Gonorrhoea: 2 tablets every 12 hours for two days or 2.5 tablets followed by a further dose of 2.5 tablets after 8 hours.

Sulfamethoxazole with TMP tablet: over 12 years

• For mild to moderate infections: 2 tablets twice daily.
• For severe infections: 2 tablets thrice daily.
• Long term therapy: (>14 days): 1 tablet twice daily.

Sulfamethoxazole with TMP suspension: Under 12 years

• 6-12 years: 2 teaspoonful twice daily.
• 6 month-5 years: 1 teaspoonful twice daily.
• 6 weeks-6 months: 0.5 teaspoonful twice daily.

Commonly associated side effects include-

• Crystalluria
• Hemolysis
• Dizziness
• Headache
• Lethargy
• Diarrhea
• Anorexia
• Nausea
• Vomiting
• Rash

Dizziness

Headache

Rash

Anorexia

Because the medicine interferes with the conversion of Folic acid to Folinic acid, prolonged full-dose treatment with the sulfamethoxazole-trimethoprim combination increases the risk of macrocytic anemia. Folinic acid can be given to reverse this if it happens. When delivering this combination to diabetic patients on a sulphonylurea treatment, it's important to keep in mind that the sulphonylurea's action may be potentiated.